质子治疗肿瘤研究的可视化分析  

Visualization Analysis of Proton Therapy for Tumors

作　　者：廖亦然 田金徽[2] 张秋宁[3] 邵丽华 杨震 王小虎[3] Liao Yiran;Tian Jinhui;Zhang Qiuning;Shao Lihua;Yang Zhen;Wang Xiaohu(The First Clinical Medical College of Lanzhou University,Lanzhou 730000,Gansu,China;Evidence Based Medicine Center of Lanzhou University,Lanzhou 730000,Gansu,China;Gansu Provincial Cancer Hospital,Lanzhou 730000,Gansu,China;School of Basic Medical Science,Lanzhou University,Lanzhou 730000,Gansu,China)

机构地区：[1]兰州大学第一临床医学院,兰州730000 [2]兰州大学循证医学中心,兰州730000 [3]甘肃省肿瘤医院,兰州730000 [4]兰州大学基础医学院,兰州730000

出　　处：《肿瘤预防与治疗》2019年第1期54-60,共7页Journal of Cancer Control And Treatment

基　　金：国家自然科学基金(编号:81160283,81372419)~~

摘　　要：目的:利用可视化方法揭示质子治疗肿瘤的研究现状与热点。方法:检索PubMed、EMBASE数据库,纳入质子治疗肿瘤相关文献,运用BICOMS-2分析软件对文献资料进行提取和整理,并利用NetDraw和gCLUTO绘制网络关系图和进行聚类分析。结果:以质子治疗肿瘤为主题的文献共6 644篇,最终纳入刊载在771种期刊上含有2 687个关键词的文献4 257篇,来自于70个国家1 820个单位的10 375名作者。1972～2018年,文献量以美国、日本、德国居多,总体呈阶梯式上升,以2006年、2012年波动最大。对主要关键词进行聚类分析显示,研究涉及三大主题:1.质子治疗前列腺癌、非小细胞肺癌、儿童肿瘤及肝细胞癌等肿瘤治疗的研究及其剂量分布、放射生物效应、放射损伤的研究;2.质子治疗脊索瘤、颅底肿瘤、软骨肉瘤的研究;3.质子治疗肿瘤相关设备、程序、运算法则的研究。结论:开展质子治疗肿瘤研究的国家、单位、作者众多,但以美国、日本、德国为主导。其研究主题主要涉及质子的相关设备程序、质子的放射物理特性及放射生物效应、质子治疗各类肿瘤及放射损伤等研究。Objective:To reveal the current situation of proton therapy for tumors by visualization approach,and provide a reference for further research in this field.Methods :We searched the PubMed and EMBASE.com and included literature on proton therapies for tumors.Information including author,employer,country,publishing journal,publishing year,and keyword were extracted and sorted by BICOMS-2 software.NetDraw was used to draw social relation diagrams,and the cluster analysis of keywords was conducted by gCLUTO.Results:In total,6,644 articles were obtained,and 4,257 articles were finally selected.Since 1972,4,257 articles with 2,687 keywords written by 10,375 authors from 180 employers in 70 countries were published in 771 journals.From 1972 to 2018,the volume of literature,which rose in general,was dominated by the United States,Japan and Germany.It fluctuated substantially from 2006 to 2012.Cluster analysis of keywords showed that the research involved three major topics:1.Studies on proton therapy for prostate cancer,non-small cell lung cancer, children's tumors and hepatocellular carcinoma,and on their dose distribution,radiobiological effects and radiation damage;2.Proton therapy for chordoma,skull base tumors and chondrosarcoma;3.Research on equipment,programs and algorithm for proton tumors.Conclusion:Research on proton therapy for tumors has been carried out by many authors,employers and countries,especially in the United States,Japan, Germany.The main research topics are related to proton related equipment and procedures,radiophysical properties and radiobiological effects of proton,various tumor treatments and radiation damage proton therapy by etc.

关 键 词：质子治疗 肿瘤 可视化分析 

分 类 号：R730.55[医药卫生—肿瘤]