针刺联合血塞通注射液对脑梗死患者神经功能缺损及细胞因子水平影响  

Effect of Acupuncture Combined with Xuesaitong Injection on Neurological Deficit and Cytokine Levels in Patients with Cerebral Infarction

作　　者：张东 焦富英 韩冰凌 于乐 刘桑 李智 吴旭 ZHANG Dong;JIAO Fuying;HAN Bingling;YULe;LIU Sang;LI Zhi;WU Xu(The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 100034,Liaoning,China)

机构地区：[1]辽宁中医药大学附属第二医院

出　　处：《辽宁中医药大学学报》2019年第1期141-144,共4页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：辽宁省中医药临床学科能力建设项目(2013-Lnzyxzk-05);辽宁省教育厅资助项目(L2015336);沈阳市科技局资助项目(17-230-9-19)

摘　　要：目的:探讨针刺联合血塞通注射液对脑梗死患者神经功能缺及细胞因子水平的影响。方法:采用病例对照研究的方法对2017年3月-2018年1月于我院住院的100例脑梗死患者进行实验研究。将患者随机分配为两组,每组患者50例,其中对照组患者使用血塞通注射液进行治疗,实验组患者在此基础上使用针刺联合治疗,两组患者均治疗1个月。治疗结束后计算临床总有效率,观察治疗前后两组患者神经功能缺损评分,测定一氧化氮(NO)、一氧化氮合酶活性(NOS)、血清丙二醛(MDA)、超氧化物歧化酶(SOD)含量,血液流变指标及细胞因子水平变化。结果:实验组临床总有效率为86.00%,对照组临床总有效率为70.00%,实验组总有效率优于对照组(P<0.05);两组患者经过治疗后神经功能缺损评分均有所升高,实验组升高更为明显(P<0.05);经过治疗后两组患者MDA水平降低,SOD、NO、NOS水平升高(P<0.05),但实验组变化更为明显(P<0.05);两组患者经过治疗后血液流变学指标均有所降低(P<0.05),但实验组降低更为明显(P<0.05);经过治疗后两组患者IL-6及TNF水平降低,IL-10水平升高(P<0.05),但实验组变化更为明显(P<0.05)。结论:针刺联合血塞通具有舒筋活络、行气活血化瘀的作用,可以明显改善脑梗死患者神经功能缺损情况,改善细胞因子水平,临床上值得应用推广。Objective:The purpose of this study was to investigate the effect of acupuncture combined with Xuesaitong Injection on neurological deficit and cytokine levels in patients with cerebral infarction.Methods:A case-control study was conducted on 100 hospitalized patients with cerebral infarction in our hospital from March 2017 to January 2018. Patients were randomly divided into two groups,50 patients in each group,the control group patients were treated with Xuesaitong Injection,and the experimental group patients were treated with acupuncture combined treatment on this basis,both groups of patients were treated for 1 month. After the treatment,the Neurological Function Defect Scale of the two groups were observed before and after treatment. Measured the contents of nitric oxide(NO),nitric oxide synthase activity(NOS),serum malondialdehyde(SOD),hemorheological indexes and changes in cytokine levels,and calculated and compared the total clinical effective rate. Results:Total clinical effective rate of experimental group and control group were 86.00% and 70.00%,respectively. The total effective rate in the experimental group was better compared with control group(P<0.05). After treatment,neurological deficit scores were increased in both groups,but the experimental group was significantly higher(P<0.05). MDA level was decreased,SOD,NO and NOS levels were increased in both groups,but the changes in the experimental group were more significant(P<0.05). The hemorheology indexes of the two groups were decreased after treatment(P<0.05),but the experimental group was significantly lower(P<0.05). Both groups IL-6 levels and TNF levels decreased,and the IL-10 level increased(P<0.05),but the changes in experimental group were more significant(P<0.05). Conclusion:Acupuncture combined with Xuesaitong Injection has the functions of activating collaterals,promoting Qi circulation,activating blood circulation and removing blood stasis,can obviously improve the neurological deficit and cytokine levels of patients with cerebral infa

关 键 词：针刺 血塞通 脑梗死 神经功能缺损 细胞因子水平 

分 类 号：R743.33[医药卫生—神经病学与精神病学]