AT2R、MMP1在三阴性乳腺癌中的表达及预后意义  

Expression of AT2R and MMP1 in triple negative breast cancer and its prognostic significance

作　　者：陈雪松[1] 李玉[2] 郑红霞 李美楠 王丹丹[1] 靳小迎 CHEN Xue-song;LI Yu;ZHENG Hong-xia;LI Mei-nan;WANG Dan-dan;JIN Xiao-ying(Department of Internal Medicine,Cancer Hospital of Harbin Medical University,Harbin 150081,China;Department of Bacterial Laboratory,Harbin Center for Disease Control and Prevention,Harbin 150056,China)

机构地区：[1]哈尔滨医科大学附属肿瘤医院内科,黑龙江哈尔滨150081 [2]哈尔滨市疾病预防控制中心细菌检验科,黑龙江哈尔滨150056

出　　处：《哈尔滨医科大学学报》2018年第5期469-473,共5页Journal of Harbin Medical University

基　　金：黑龙江省教育厅科学技术项目(12541435)

摘　　要：目的研究AT2R、MMP1在乳腺癌组织中的表达情况并探讨其临床意义。方法采用免疫组化方法(SP法),对92例三阴性乳腺癌患者石蜡包埋组织切片中AT2R、MMP1的表达进行检测,分析其表达和临床病理因素的关系。结果在三阴性乳腺癌组织中,AT2R的阳性表达率为45. 6%(42/92),AT2R表达与腋淋巴结转移、MMP1表达呈负相关(P <0. 05),与患者年龄、肿瘤大小、P53、Ki-67表达差异均无统计学意义(P> 0. 05); MMP1的阳性表达率为47. 8%(44/92),MMP1表达量与腋淋巴结转移呈正相关,差异有统计学意义(P <0. 05),与患者年龄、肿瘤大小、P53、Ki-67表达差异无统计学意义(P>0. 05); AT2R的表达与MMP1表达呈负相关(P <0. 05); AT2R表达后乳腺癌患者的DFS明显延长,但不是独立预后因素。结论 AT2R可能通过MMP1参与三阴性乳腺癌肿瘤细胞的增殖和侵袭。Objective To study the expression of AT2 R and MMP1 in breast cancer and to explore its clinical significance. Methods The expression of AT2 R and MMP1 in paraffin embedded tissue sections of 92 patients with triple-negative breast cancer was detected by immunohistochemical method( SP method),and the relationship between their expression and clinicopathological factors was analyzed. Results The positive expression rate of AT2 R was 45. 6%( 42/92) in triple negative breast cancer tissues. AT2 R expression was negatively correlated with axillary lymph node metastasis and MMP1 expression( P < 0. 05). There was no significant difference in expression between AT2 R and the age,tumor size,P53,Ki-67( P > 0. 05).The positive expression rate of MMP1 was 47. 8%( 44/92). The expression of MMP1 was significantly different from that of axillary lymph node metastasis,and had no significant difference with the age,tumor size,P53 and Ki-67. The expression of AT2 R was negatively correlated with the expression of MMP1;the DFS of breast cancer patients after AT2 R expression was significantly prolonged,but it was not an independent prognostic factor. Conclusion AT2 R may participate in the proliferation and invasion of triple negative breast cancer cells through MMP1.

关 键 词：AT2受体 MMP1 三阴性乳腺癌 

分 类 号：R737.9[医药卫生—肿瘤]