Rho/ROCK信号通路与脑动脉硬化患者血液流变学的相关性研究  

Study on the correlation between Rho/ROCK signal pathway and hemorheology in patients with cerebral arteriosclerosis

作　　者：许忠波 杜婷婷[1] 冯欣 金桂林[4] XU Zhongbo;DU Tingting;FENG Xin;JIN Guilin(Emergency Department,Affiliated Hospital of Jiangxi University of Chinese Medicine,Nanchang,Jiangxi 330006,China;Clinical Laboratory,Affiliated Hospital of Jiangxi University of Chinese Medicine,Nanchang,Jiangxi 330006,China;Health Education Department,Maternal and Child Health Hospital of Jiangxi Province,Nanchang,Jiangxi 330006,China)

机构地区：[1]江西中医药大学附属医院急诊科,江西省南昌市330006 [2]江西中医药大学附属医院 [3]江西省妇幼保健院健康教育科,江西省南昌市330006 [4]江西中医药大学附属医院检验科,江西省南昌市330006

出　　处：《中国动脉硬化杂志》2019年第1期51-54,共4页Chinese Journal of Arteriosclerosis

基　　金：江西省卫生计生委中医药科研课题(2016B074);江西省卫生计生委科技计划资助项目(20175334)

摘　　要：目的探讨Rho/ROCK信号通路与脑动脉硬化(CAS)患者血液流变学之间的关系。方法选择CAS患者80例及健康体检者80例,收集血液样本,检测相应生物化学指标、Ras同族体基因家族成员A(RhoA)、Rho激酶2(ROCK2)水平及血细胞比容、全血表观黏度(高切、低切)、血浆黏度。比较2组血液流变学指标、RhoA、ROCK2水平;分析CAS患者RhoA、ROCK2水平与血液流变学指标的相关性。结果 CAS组吸烟比例、体质指数、空腹血糖、餐后2 h血糖、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、甘油三酯、血清同型半胱氨酸均高于对照组(P<0.05)。CAS组血细胞比容、全血表观黏度(高切、低切)、血浆黏度、ROCK2、RhoA水平均高于对照组(P <0.05)。Pearson相关分析及多重线性回归分析显示,ROCK2水平与血细胞比容、全血表观黏度高切、低切、血浆黏度呈正相关; RhoA水平与全血表观黏度(高切、低切)呈正相关。结论 Rho/ROCK信号通路与CAS患者血液流变学的异常密切相关,可能参与了CAS的发生发展。Aim To investigate the relationship between Rho/ROCK signal pathway and hemorheology in patients with cerebral arteriosclerosis(CAS).Methods Blood samples were collected from 80 CAS patients and 80 healthy persons.The biochemical parameters,the levels of Ras homolog gene family member A(RhoA) and Rho-associated kinase 2(ROCK2),blood cell-specific volume,whole blood apparent viscosity(high shear and low shear) and plasma viscosity were measured.Hemorheological indexes,RhoA and ROCK2 levels were compared between the two groups.The correlations between RhoA,ROCK2 levels and hemorheological parameters were analyzed in CAS patients.Results The smoking rate,body mass index,fasting plasma glucose,2-hour postprandial plasma glucose,high density lipoprotein cholesterol,low density lipoprotein cholesterol,triglyceride and serum homocysteine in CAS group were higher than those in control group(P<0.05).The blood cell-specific volume,whole blood apparent viscosity(high shear and low shear),plasma viscosity,ROCK2 and RhoA levels in CAS group were higher than those in control group(P<0.05).Pearson correlation analysis and multiple linear regression analysis showed that serum ROCK2 level was positively correlated with blood cell-specific volume,whole blood apparent viscosity(high shear and low shear) and plasma viscosity;RhoA level was positively correlated with whole blood apparent viscosity(high shear and low shear).Conclusion Rho/ROCK signal pathway is closely related to abnormal hemorheology in CAS patients,and it may be involved in the occurrence and development of CAS.

关 键 词：RHO/ROCK信号通路 脑动脉硬化 血液流变学 相关性 

分 类 号：R743.1[医药卫生—神经病学与精神病学] R5[医药卫生—临床医学]