丁苯酞联合依达拉奉治疗通过降低颈动脉内膜中膜厚度改善老年急性脑梗死患者神经功能  

Butylphthalide combined with edaravone improves neurological function in elderly patients with acute cerebral infarction by reducing carotid intima-media thickness

作　　者：陈海云 何超明[1] CHEN Haiyun;HE Chaoming(The Third People's Hospital of Hainan Province,Sanya,Hainan 572000,China)

机构地区：[1]海南省第三人民医院,海南省三亚市572000

出　　处：《中国动脉硬化杂志》2019年第1期65-68,共4页Chinese Journal of Arteriosclerosis

摘　　要：目的探讨丁苯酞联合依达拉奉治疗对老年急性脑梗死患者颈动脉内膜中膜厚度和神经功能的影响。方法纳入2014年1月至2016年3月在我院神经内科收治的老年急性脑梗死患者92例,随机分为依达拉奉治疗组和丁苯酞联合依达拉奉治疗组(简称联合治疗组),每组46例。依达拉奉治疗组给予依达拉奉治疗,联合治疗组同时给予依达拉奉和丁苯酞治疗,共治疗90天。观察两组治疗效果,评估颈动脉内膜中膜厚度和斑块面积,应用NIHSS评分、改良的Rankin量表(m RS)评分和Barthel指数评价神经功能。同时,观察两组患者不良反应的发生情况。结果联合治疗组总有效率显著高于依达拉奉治疗组(P<0.05)。治疗后,两组患者颈动脉内膜中膜厚度和斑块面积均较治疗前显著降低(P<0.05),且联合治疗组颈动脉内膜中膜厚度和斑块面积显著低于依达拉奉治疗组(P<0.05);联合治疗组NIHSS评分、m RS评分低于依达拉奉治疗组(P<0.05),Barthel指数显著高于依达拉奉治疗组(P<0.05);两组患者不良反应发生率无明显差异(P>0.05)。结论丁苯酞联合依达拉奉治疗可显著降低老年急性脑梗死患者颈动脉内膜中膜厚度,改善其神经功能,临床疗效显著,安全性较高。Aim To investigate the effects of butylphthalide combined with edaravone on carotid intima-media thickness(IMT) and neurological function in elderly patients with acute cerebral infarction.Methods From January 2014 to March 2016,92 elderly patients with acute cerebral infarction in the Department of Neurology in our hospital were randomly divided into edaravone treatment group and butylphthalide combined edaravone treatment group(combined treatment group),46 cases in each group.Edaravone treatment group was treated with edaravone,and combined treatment group was treated with edaravone and butylphthalide for 90 days.The therapeutic effects of the two groups were observed,carotid IMT and plaque area were evaluated,and neurological function was evaluated by NIHSS score,modified Rankin scale(m RS) score and Barthel index.At the same time,the occurrence of adverse reactions in the two groups was observed.Results The total effective rate of combined treatment group was significantly higher than that of edaravone treatment group(P<0.05).After treatment,carotid IMT and plaque area in the two groups were significantly lower than those before treatment(P<0.05),and significantly lower in the combined treatment group than those in the edaravone treatment group(P<0.05),the NIHSS score and m RS score in the combined treatment group were lower than those in the edaravone treatment group(P<0.05),and the Barthel index was significantly higher than that in the edaravone treatment group(P<0.05),there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Butylphthalide combined with edaravone can significantly reduce carotid IMT in elderly patients with acute cerebral infarction and improve their nerve function,the clinical effect is remarkable and the safety is high.

关 键 词：丁苯酞 急性脑梗死 内膜中膜厚度 神经功能 

分 类 号：R741[医药卫生—神经病学与精神病学]