富含甘油三酯脂蛋白代谢及其在动脉粥样硬化中的作用  

Roles of lipoprotein lipase in triglyceride metabolism and atherosclerosis

作　　者：熊芳 王宗保[1,2] 唐朝克 XIONG Fang;WANG Zongbao;TANG Chaoke(Institute of Cardiovascular Disease,Key Laboratory for Atherosderology of Human Province,Medical Research Center, ttunan Province Cooperative Innovation Center for Molecular Target New Drug Study,University of South China,Hengyang,Hunan 421001,China;School of Pharmacy,University of South China,Hengyang,Hunan 421001,China)

机构地区：[1]南华大学心血管疾病研究所动脉硬化学湖南省重点实验室医学研究实验中心湖南省分子靶标新药研究协同创新中心,湖南省衡阳市421001 [2]南华大学药学院,湖南省衡阳市421001

出　　处：《中国动脉硬化杂志》2019年第1期81-86,共6页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金项目(81570408)

摘　　要：甘油三酯(TG)主要存在于富含甘油三酯脂蛋白(TRLs)中,TRLs代谢失调与动脉粥样硬化发生发展密切相关。脂蛋白脂酶(LPL)是一种由实质细胞分泌的糖蛋白,可将TRLs中的TG分解为游离脂肪酸。许多因子通过调控LPL表达与活性影响TRLs代谢及动脉粥样硬化进程。因此,阐明TRLs代谢及调控机制对于心血管疾病防治具有重要意义。Triglyceride(TG) is predominantly present in triglyceride-rich lipoproteins(TRLs).Dysregulation of TRL metabolism is closely associated with the occurrence and development of atherosclerosis.Lipoprotein lipase(LPL),a glycoprotein secreted by parenchyma cells,can cleave TG within the TRLs to produce free fatty acid.A variety of factors are involved in TRL metabolism and atherosclerosis progression by regulating LPL expression and activity.Thus,clarifying the role TRL metabolism and its regulatory mechanisms could have significant implications for the prevention and treatment of cardiovascular disease.

关 键 词：甘油三酯 富含甘油三酯脂蛋白 脂蛋白脂酶 动脉粥样硬化 

分 类 号：R363[医药卫生—病理学] R5[医药卫生—基础医学]