外周血循环肿瘤细胞上皮-间质转化机制调控的EP方案治疗小细胞肺癌的研究  

Effects of EP therpy regulated by epithelial-mesenchymal transition mechanism in peripheral blood circulating tumor cells on the treatment of small-cell lung cancer

作　　者：聂启鸿 刘华峰[1] 卢燕军 NIE Qihong;LIU Hua feng;LU Yanjun(Department of Oncology,Ganzhou People's Hospital,Ganzhou,Jiangxi 341000,China)

机构地区：[1]江西省赣州市人民医院肿瘤科,341000

出　　处：《重庆医学》2019年第1期91-93,共3页Chongqing medicine

基　　金：江西省卫生和计划生育委员会科技计划项目(20177257)

摘　　要：目的研究外周血循环肿瘤细胞(CTCs)上皮-间质转化机制调控的EP方案治疗小细胞肺癌的效果。方法以该院2015年5月至2017年5月收治的100例小细胞肺癌患者(观察组)为研究对象,研究依托泊苷联合顺铂(EP)方案治疗小细胞肺癌的临床效果,以该院同期伊立替康联合顺铂(IP)方案治疗的100例小细胞肺癌患者为对照组,分析治疗前后CTCs及钙离子依赖的细胞黏附素家族(E-cadherin)、细胞角蛋白-19(CK-19)和波形蛋白(Vimentin)变化。结果观察组完全缓解(CR)+部分缓解(PR)比例为60.0%,明显高于对照组(P<0.05);两组治疗后CTCs阳性表达例数及计数均明显降低(P<0.05),E-cadherin、β-catenin、Vimentin蛋白水平明显降低(P<0.05),而CK-19蛋白水平明显升高(P<0.05),观察组患者的上述指标降低更显著(P<0.05)。结论 EP治疗方案对小细胞肺癌有较好的效果。Objective To study the EP therpy regulated by epithelial-mesenchymal transition mechanism in peripheral blood circulating tumor cells(CTCs)in the treatment of small-cell lung cancer.Methods100 patients with small-cell lung cancer(the obseration group)from May 2015 to May 2017 in our hospital were enrolled.The clinical effect of etoposide combined with cisplatin(EP)in the treatment of small-cell lung cancer was studied.100 patients treated with illiteky combined with cisplatin(IP)in the same period in the hospital were used as the control group.The changes of CTCS E-cadherin,cytokeration-19(CK-19)and Vimentin in peripheral blood were analyzed before and after treatment.Results Complete response(CR)+partly response(PR)ratio in the observation group was 60%,significantly higher than that in the control group(P<0.05).The cases and counts of CTC-positive expression significantly decreased(P<0.05)after treatment.E-cadherin,β-catenin,Vimentin protein decreased significantly while CK-19 increased significantly(P<0.05).The reduction of the above indicators was more significant in the observation group.Conclusion EP therpy has a good effect on the extensive stage of small cell lung cancer.

关 键 词：临床方案 上皮-间质转化 癌 小细胞 肺肿瘤 肿瘤循环细胞 

分 类 号：R734.2[医药卫生—肿瘤]