放大内镜与超声内镜对早期食管癌浸润深度诊断价值的Meta分析  

Magnifying endoscopy and endoscopic ultrasonography for the diagnosis of invasion depth of early esophageal cancer:a Meta-analysis

作　　者：高亚东 屈亚威[1] 刘海峰[1,2] GAO Yadong;QU Yawei;LIU Haifeng(Department of Gastroenterology,General Hospital of Chinese People's Armed Police Force,Beijing 100039,China Clinical College,General Hospital of Chinese People's Armed Police Forces,Anhui Medical University,Hefei 230032,China)

机构地区：[1]武警总医院消化内科,北京100039 [2]安徽医科大学武警总医院临床学院,合肥230032

出　　处：《重庆医学》2019年第1期98-101,105,共5页Chongqing medicine

基　　金：国家自然科学基金资助项目(81471700)

摘　　要：目的系统评价放大内镜和超声内镜对评估早期食管癌浸润深度的临床价值。方法计算机检索PubMed、Ovid Medline、Embase、Cochrane Library、CBM、中国期刊全文数据库(CNKI)、维普、万方数据库中的相关文献,对纳入文献进行质量评价和异质性检验,汇总合并灵敏度、特异度,并绘制汇总受试者工作特征曲线(SROC),计算曲线下面积(AUC)。结果最终纳入6篇文献,包含640例患者进行合并分析。放大内镜的汇总灵敏度、汇总特异度、阳性似然比、阴性似然比、AUC分别为0.79(95%CI:0.71~0.86)、0.97(95%CI:0.94~0.98)、18.19(95%CI:5.75~57.54)、0.25(95%CI:0.18~0.35)、0.831 8;超声内镜分别为0.82(95%CI:0.72~0.89)、0.89(95%CI:0.85~0.92)、6.34(95%CI:4.46~9.01)、0.23(95%CI:0.15~0.36)、0.922 7。两者AUC值比较,差异无统计学意义(P>0.05)。结论两种内镜的准确性相当,均有一定的临床价值。Objective Meta-analysis was performed to provide accurate evidence regarding the preferred diagnostic method magnifying endoscopy(ME)or endoscopic ultrasonography(EUS)for the diagnosis of invasion depth of early esophageal cancer(EEC).Methods Conducted a systematic review using PubMed,Embase,Ovid Medline,the Cochrane Library,CNKI,WanFang,WIP and CBM to identify relevant peer-review studies and evaluated the quality of diagnostic studies.Summary estimates of specificity and specificity were calculated to draw summarized receiver-operating characteristic curves(SROC).Results 6 studies with a total of 640 patients were selected in our analysis.The overall sensitivity,specificty,positive likelihood ratio(PLR),negative likelihood ratio(NLR)and AUC of assessing ME as a method to the depth of invasion of early esophageal cancer were 0.79(95%CI:0.71-0.86),0.97(95%CI:0.94-0.98),18.19(95%CI:5.75-57.54),0.25(95%CI:0.18-0.35),0.831 8,respectively.Additionally,the overall sensitivity,specifcity,PLR,NLR and AUC of EUS were 0.82(95%CI:0.72-0.89),0.89(95%CI:0.85-0.92),6.34(95%CI:4.46-9.01),0.23(95%CI:0.15-0.36),0.922 7,respectively.There was no statistical difference between ME and EUS in the AUC values(P>0.05).Conclusion The diagnostic accuracy is equivalent between ME and EUS,and both of them play an important role in judging the invasion depth of early esophageal cancer.

关 键 词：食管肿瘤 放大内镜 超声内镜 META分析 

分 类 号：R735.1[医药卫生—肿瘤]