心肺耦合分析用于帕金森病的临床研究  

Cardiopulmonary coupling analysis in Parkinson's disease

作　　者：叶指南 陈瑛[1] 徐浩[1] 许杭雨[1] 何迎晔 李海军[1] Ye Zhinan;Chen Ying;Xu Hao;Xu Hangyu;He Yingye;Li Haijun(Unit I,Department of Neurology,Taizhou Municipal Hospital,Taizhou 318000,China)

机构地区：[1]台州市立医院神经内一科,318000

出　　处：《中华神经医学杂志》2019年第1期28-32,共5页Chinese Journal of Neuromedicine

摘　　要：目的明确心肺耦合(CPC)分析在评估帕金森病(PD)患者睡眠质量中的作用,探讨CPC分析结果与主观睡眠质量的相关性。方法选择自2015年10月至2017年12月台州市立医院神经内一科收治的PD患者60例为PD组,同期该院体检的健康人员45例为对照组。采用CPC以及匹兹堡睡眠质量指数量表(PSQI)对2组成员进行睡眠质量评估,比较其CPC变量及PSQI分数的差异,以及PD组CPC各变量与PSQI分数的相关性。结果(1)PD组的高频耦合(HFC)、睡眠效率显著低于对照组,差异有统计学意义(P<0.05);而PD组的极低频耦合、睡眠潜伏期显著高于对照组,差异有统计学意义(P<0.05)。(2)PD组的PSQI评分显著高于对照组,差异有统计学意义(P<0.05)。PD组的PSQI评分与HFC比例呈负相关关系(r=-0.391,P=0.002)。结论CPC能客观反映PD患者的睡眠质量,可作为一种评价PD患者睡眠质量的新技术。Objective To evaluate the role of cardiopulmonary coupling (CPC) analysis in evaluating the sleep quality of patients with Parkinson's disease (PD), and explore its correlation with subjective complaints in patients with PD. Methods Sixty patients with PD, admitted to our hospital from October 2015 to December 2017, and 45 healthy controls accepted physical examinations were enrolled. The sleep qualities of all subjects were assessed using CPC and Pittsburgh sleep quality index (PSQI). Independent-sample t test was used to compare the CPC variables and PSQI results, and the correlations between CPC variables and PSQI results were analyzed. Results (1) High-frequency coupling (HFC) and sleep efficiency of PD patients were significantly lower than those of healthy controls (P<0.05);very low-frequency coupling and sleep latency of PD patients were significantly higher than those of healthy controls (P<0.05). (2) Results of PSQI in the PD patients were significantly increased as compared with those in the control group (P<0.05);there was a negative correlation between PSQI results and HFC ratio in the PD group (r=-0.391, P=0.002). Conclusion CPC analysis is effective in reflecting the subjective sleep quality of PD patients and can be used as a new technology in sleep monitoring.

关 键 词：心肺耦合分析 帕金森病 睡眠监测 

分 类 号：R742.5[医药卫生—神经病学与精神病学]