血卟啉衍生物纳米药物在肝癌患者体内抑癌效果及其机制研究  

ANTI-CANCER EFFECT AND MECHANISM OF HEMATOPORPHYRIN DERIVATIVES NANOPARTICLES IN PATIENTS WITH HEPATOCELLULAR CARCINOMA

作　　者：魏霞[1] 范成琼 Wei Xia;Fan Chengqiong(Department of Pharmacy ,the Central Hospital of Chongqing Three Gorges,Chongqing 404000 ,China)

机构地区：[1]重庆三峡中心医院药学部,重庆市404000

出　　处：《中国煤炭工业医学杂志》2019年第1期6-10,共5页Chinese Journal of Coal Industry Medicine

基　　金：重庆市科技计划项目(编号:2015120073)

摘　　要：目的探讨血卟啉衍生物纳米药物在肝癌患者体内的抑癌效果及其作用机制。方法回顾性分析我院2012年4月——2015年3月收治入院的75例肝癌患者病例资料,其中35例为对照组,采用肝癌常规化疗,40例为观察组,采用常规化疗联合血卟啉衍生物纳米药物光动力治疗,比较二组患者HepG2凋亡情况及bcl-2蛋白及bax蛋白表达水平,并统计分析组间近期疗效和远期生存率及肝功能变化。结果治疗后观察组患者肝癌细胞HepG2中bcl-2蛋白水平显著低于对照组[(5.12±0.75)%vs.(38.56±9.75)%],bax蛋白水平明显高于对照组[(33.18±4.85)%vs.(26.05±2.02)%],组间比较差异有统计学意义(P<0.05),且观察组HepG2细胞凋亡率显著高于对照组[(25.26±9.75)%vs.(9.15±2.48)%],组间比较差异有统计学意义(P<0.05)。观察组近期总有效率为85.00%,高于对照组的62.86%,组间比较差异有统计学意义(P<0.05);观察组生存期≥5年所占比例显著高于对照组(27.50%vs.8.57%),组间比较差异有统计学意义(P<0.05);且观察组1年(87.50%)、2年(72.50%)及4年(32.50%)存活率均显著高于对照组(68.57%、42.86%、11.43%),组间比较差异有统计学意义(P<0.05)。此外,治疗前组间AST、ALT比较差异无统计学意义(P>0.05),治疗后二组AST、ALT均显著改善,且观察组AST、ALT改善效果显著优于对照组,比较差异有统计学意义(P<0.05)。结论血卟啉衍生物纳米药物用于肝癌治疗,可有效促进肝癌细胞凋亡,改善肝功能,提高临床疗效和远期生存率。Objective To investigate the anti-cancer effect and mechanism of hematoporphyrin derivatives nanoparticles in patients with hepatocellular carcinoma.Methods A retrospective analysis of seventy-five cases with hepatocellular carcinoma in the Central Hospital of Chongqing Three Gorges from April 2012 to March 2015 was taken,among them,35 cases received liver cancer conventional chemotherapy were set as the control group,40 cases received conventional chemotherapy combined with hematoporphyrin derivative nano drug photodynamic treatment were selected the observation group,HepG2 apoptosis,bcl-2 protein and bax protein expression level between the two groups were compared,and a statistical analysis of recent curative effect,long-term survival rate and liver function changes between groups was taken.Results Bcl-2 protein level in hepatocellular carcinoma cells HepG2 of the observation group after the treatment was significantly lower than that of the control group((5.12±0.75)%vs.(38.56±9.75)%),the bax protein level of the observation group was significantly higher than that of the control group((33.18±4.85)%vs.(26.05±2.02)%),the difference between groups was significant(P<0.05),the HepG2 cells apoptosis rate of the observation group was significantly higher than that of the control group((25.26±9.75)%vs.(9.15±2.48)%),there was a significant difference between the two groups(P<0.05).The total effective rate of the observation group was 85%recently,which was higher than that of the control group(62.86%),there was statistical significance between the groups(P<0.05);The proportion of life cycle≥5 years of the observation group was significantly higher than that of the control group(27.50%vs.8.57%),statistical difference between groups was significant(P<0.05);the 1 year,2 year and 4 year survival rate of the observation group(87.50%,72.50%,32.50%)were significantly higher than those of the control group(68.57%,42.86%,11.43%).Data compared between the two groups showed statistical difference(P<0.05).In addition,there

关 键 词：血卟啉衍生物 纳米药物 肝癌 抑癌效果 

分 类 号：R735.7[医药卫生—肿瘤]