肿瘤细胞主导的血管生成拟态与肿瘤侵袭转移  

Vasculogenic mimicry dominated by tumors and migration and invasion of carcinomas

作　　者：饶慕圣 曹胜华[1] 徐兴东[1] 王刚[1] 王学成 Rao Musheng;Cao Shenghua;Xu Xingdong;Wang Gang;Wang Xuecheng(Department of General Surgery,the People's Hospital of China Three Gorges University,Yiehang First People's Hospital,Yichang 443000,China;Department of Blood Transfusion,Second Hospital of Huangshi, Huangshi 435000,China)

机构地区：[1]三峡大学人民医院,宜昌市第一人民医院普外科,443000 [2]黄石市第二医院输血科,435000

出　　处：《国际外科学杂志》2019年第1期60-63,共4页International Journal of Surgery

基　　金：湖北省自然科学基金(2018CFB440).

摘　　要：实体肿瘤的生长依赖于从现有血管中产生新血管,即肿瘤血管新生。恶性肿瘤在侵袭转移过程中需要消耗大量物质,为满足自身需求,肿瘤细胞会通过不同的方式产生新的脉管系统,以供应营养和氧气,以及消除自身代谢废物。血管生成拟态是一种由肿瘤细胞自身主导的血管生成方式,不同于传统的内皮细胞血管生成模式,其在肿瘤的侵袭转移过程中发挥重要作用。本文将对血管生成拟态与肿瘤侵袭转移、肿瘤血管生成的关系,以及相关的信号通路作一综述。The growth of solid tumors is dependent on new blood vessels generated from existed ones,that is tumor angiogenesis.Much material consumption is required in the invasion and metastasis of malignant tumors,to meet the own needs of oxygen and nutrients and remove the metabolic wastes from them,tumor cells will generate new vasculature through different ways.Vasculogenic mimicry is a kind of angiogenesis dominated by tumor cells,it is one style of vascular pattern that is different from traditional endothelial cells pattern.Vasculogenic mimicry plays an important role in the invasion and metastasis of tumors.This article will review the relationship between vasculogenic mimicry and tumor invasion and metastasis,tumor angiogenesis,and related signaling pathways.

关 键 词：肿瘤转移 肿瘤侵润 血管生成拟态 

分 类 号：R73-37[医药卫生—肿瘤]