活血消脂胶囊对脂肪肝患者SOD、MDA及CYP450的影响  

The therapeutic effect of Huoxuexiaozhi capsule on SOD,MDA and CYP450 in treating fatty liver disease

作　　者：杨如意[1] 曹昌霞[1] 郭占芳[1] 徐海珍[1] 赵文玲[1] 刘永萍[1] 孙兆[1] 王君[1] 王宏斌 YANG Ru-yi;CAO Chang-xia;GUO Zhan-fang(Department of Traditional Chinese Medicine,Qinghai University Hospital,Xining ,Qinghai 810016,China)

机构地区：[1]青海大学附属医院中医科,青海西宁810016

出　　处：《中华全科医学》2019年第2期291-294,共4页Chinese Journal of General Practice

基　　金：青海省中藏医局研究课题项目(2015104)

摘　　要：目的观察中藏药活血消脂胶囊对脂肪肝的疗效及对血清超氧化物歧化酶(SOD)及丙二醛(MDA)、细胞色素P450(CYP450)的影响,并探讨其作用机制。方法采用前瞻性随机对照研究方法,选择2014—2016年青海大学附属医院确诊的脂肪肝患者100例,采用随机数字表法将患者分为治疗组和对照组,2组各50例,治疗组患者口服活血消脂胶囊,4粒/次,3次/d;对照组患者口服东宝甘泰(复方蛋氨酸胆碱)片,3片/次,3次/d。5周为一疗程。疗程结束后观察临床疗效。观察2组的症状、肝功能指标及血清SOD及MDA、CYP450的变化并进行分析研究。结果治疗组临床治愈14例,显效18例,好转12例,无效6例,总有效率为88.0%,对照组临床治愈7例,显效11例,好转18例,无效14例,总有效率为72.0%,2组比较差异有统计学意义(P<0.01);与对照组比较,活血消脂胶囊能显著改善脂肪肝患者食欲不振、脘腹胀满、胁肋胀痛、恶心呕吐、便溏、乏力等临床症状,差异有统计学意义(均P<0.05);与对照组比较,活血消脂胶囊能显著改善脂肪肝患者血ALP、ALT、AST及γ-GT水平,差异有统计学意义(均P<0.01);活血消脂胶囊能显著升高脂肪肝患者血清SOD水平,降低MDA及CYP450水平,2组治疗后比较,差异有统计学意义(均P<0.01)。结论活血消脂胶囊能治疗脂肪肝,改善临床症状,改善肝功能,升高血清SOD、降低MDA及CYP450,其作用明显优于东宝甘泰片。Objective To observe the therapeutic effect of traditional Chinese medicine decoction Huoxuexiaozhi capsule on Fatty liver diseases superoxide dismutase(SOD),malondialdehyde(MDA),Cytochrome P450(CYP450) in blood serum,and approach its mechanism.Methods A prospective randomized controlled study was conducted,including100 patients who were definitely diagnosed as fatty liver and admitted into affiliated Qinghai University Hospital from January 2014 to December 2016,and they were divided into a treatment group and a control group,50 cases in each group by random number table method.Traditional Chinese medicine Huoxuexiaozhi capsule was taken orally in treatment group,4 capsules each time,three times each day,and Dongbaogantai tablet was taken orally in control group,3 Tablets each time,three times each day.One course of treatment was five weeks.After treatment,the clinic effect was analysed.the changes of patients symptoms,liver function,SOD,MDA,CYP450 in blood serum were studied and analysed.Results Fourteen cases were cured,18 cases were significantly effective,12 cases improved and 6 cases were null and void in treatment group,the totol effective rate is 88.0%.Seven cases were cured,11 cases were significantly effective,18 cases improved and 14 cases were nulland void in treatment group,the totol effective rate is 72.0%.And there were statistical significant between two groups(P < 0.01).Huoxuexiaozhi capsule improved symptoms significantly of fatty liver diseases,such as loss of appetite,often loose stools weak,abdominal distension full side rib pain,nausea and vomiting,there were statistical significant between two groups(all P < 0.05).Huoxuexiaozhi capsule improved ALT,AST,γ-GT and ALP,there were statistical significant between two groups(all P < 0.01).Huoxuexiaozhi capsule increased SOD,redused MDA and CYP450,there were statistical significant between two groups after treatment(all P < 0.01).Conclusion Huoxuexiaozhi capsule can treat fatty liver disease,improve symptoms,liver function,increase SOD,decrease MD

关 键 词：脂肪肝 活血消脂胶囊 超氧化物歧化酶 丙二醛 细胞色素P450 

分 类 号：R575.5[医药卫生—消化系统] R28[医药卫生—内科学]