ADCY-2基因rs4702484多态性与双相障碍共病肥胖的关联研究  

Association between ADCY-2 gene rs4702484 polymorphism and bipolar disorder comorbid obesity

作　　者：尹岸民 黄成兵[1] 孙晖[1] 孙太鹏 石文杰[1] 于名超 薛永[1] 陈雪菲[1] Yin An min;Huang Chengbing;Sun Hui;Sun Tai peng;Shi Wenjie;Yu Mingchao;Xue Yong;Chen Xuefei(The Third People's Hospital of Huai'an,Huai'un 223001,Jiangsu,China)

机构地区：[1]淮安市第三人民医院,江苏淮安223001

出　　处：《临床心身疾病杂志》2019年第1期1-3,共3页Journal of Clinical Psychosomatic Diseases

基　　金：淮安市重点研发计划(社会发展)项目(编号HAS2015034).

摘　　要：了解双相障碍患者ADCY-2基因rs4702484的多态性,探讨ADCY-2基因多态性与双相障碍共病肥胖的关系.方法 将108例双相障碍患者根据体质量指数25为分割点分为肥胖组(47例)和非肥胖组(61例) ,采用 PCR技术分析患者 ADCY-2基因 rs4702484的基因型和等位基因分布频率.结果 本组患者肥胖率为44%,检测到 ADCY-2基因 rs4702484位点存在CC 、CT及TT3种基因型.肥胖组患者CC基因型分布显著低于非肥胖组(P<0 .05) ,TT 基因型分布显著高于非肥胖组(P<0 .05).肥胖组患者等位基因C的分布频率显著低于非肥胖组(P<0 .05) ,等位基因T的分布频率显著高于非肥胖组(P<0 .05).结论 双相障碍和肥胖共病率高,ADCY-2基因rs4702484的C-T突变可能增加共病肥胖的风险.Objective To understand the polymorphism of ADCY-2 gene rs4702484 in patients with bipolar disorder, and to explore the relationship between ADCY-2 gene polymorphism and bipolar disorder comorbid obesity. Methods 108 patients with bipolar disorder were divided into obese group (47 cases) and non-obese group (61 cases) according to the body mass index 25. The genotype and allele distribution frequency of the ADCY-2 gene rs4702484 were analyzed by PCR. Results The obesity rate of this group of patients was 44%, and there were three genotypes of CC, CT and TT in the rs4702484 locus of ADCY-2 gene. The distribution of CC genotypes in the obese group was significantly lower than that in the non-obese group (P<0. 05), and the TT genotype distribution was significantly higher than that in the non-obese group (P<0. 05). From the allele frequency, the frequency of allele C in the obese group was significantly lower than that in the non-obese group (P<0. 05) , and the frequency of allele T was significantly higher than that in the non-obese group (P<0. 05). Conclusion Bipolar disorder and obesity have a high comorbidity rate. The C-T mutation of ADCY-2 gene rs4702484 may increase the risk of comorbid obesity.

关 键 词：双相障碍 肥胖 腺苷酸环化酶2 基因多态性 

分 类 号：R749.4[医药卫生—神经病学与精神病学]