5-芳亚甲基-2,3-二芳基噻唑-4-酮类衍生物的合成及抑菌活性研究（英文）  

Syntheses and Antifungal Activities of 5-Arylidene-2,3-diaryl-thiazolidin-4-one Derivatives

作　　者：於祥 陈娅芳 覃炎 严静 Yu Xiang;Chen Yafang;Qin Yan;Yan Jing(College of Pharmacy,Guizhou University of Chinese Medicine,Guiyang 550025;Guizhou Key Laboratory of Miao Medieine,Guizhou University of Chinese Medicine,Guiyang 550025)

机构地区：[1]贵州中医药大学药学院 [2]贵州中医药大学贵州省苗医药重点实验室,贵阳550025

出　　处：《化学通报》2019年第1期68-73,2,共7页Chemistry

基　　金：贵州中医药大学2018年度学术新苗培养及创新探索专项(黔科合平台人才[2017]5735号-22);贵州省教育厅青年人才成长项目(黔教合KY字[2017]169);贵州省苗医药重点实验室开放课题(黔苗医药K字[2017]034)资助

摘　　要：本文以多个2,3-二芳基噻唑-4-酮为底物,利用微波辅助的方法合成了18个5-芳亚甲基-2,3-二芳基噻唑-4-酮类衍生物,并测定了它们对7种植物病原菌的抑菌活性。它们的结构经熔点、1H NMR和MS确证。抑菌活性试验显示,化合物4g和4n表现出潜在的抑菌活性。A series of 5-arylidene-2,3-diaryl-thiazolidin-4-one derivatives(4a^4r)were synthesized from 2,3-diphenyl-thiazolidin-4-one via microwave irradiation,and evaluated in vitro at the concentration of 100μg/mL against seven phytopathogenic fungi,namely Fusarium graminearum,Alternaria alternata,Fusarium oxysporium f.sp.vasinfectum,Pyricularia oryzae,Valsa mali,Alternaria solani and Alternaria brassicae.All the prepared compounds were characterized for structural confirmation by meltingNMR,and MS.The activity results indicated that4g and 4n exhibit potential antifungal activities against the phytopathogenic fungi.

关 键 词：5-芳亚甲基-2 3-二芳基噻唑4-酮微波辅助 抑菌活性 

分 类 号：O626[理学—有机化学] TQ455.4[理学—化学]