药物联合感统训练对高功能孤独症谱系障碍儿童的疗效及对患儿血清脑源性神经营养因子水平的影响  

Curative effect of drug therapy combined with sensory integration training in treatment of children with high-functioning autism spectrum disorder and the influence on serum brain-derived neurotrophic factor levels in children

作　　者：黄明欣[1] 石萍[1] 于情[1] 李宇[1] HUANG Ming-Xin;SHI Ping;YU Qing(Tianiin Children's Hospital,Tianjin,300134,China)

机构地区：[1]天津市儿童医院,天津300134

出　　处：《中国妇幼保健》2019年第2期314-317,共4页Maternal and Child Health Care of China

基　　金：国家科技支撑计划重大精神疾病防治关键技术研究(2012BAI01B00)

摘　　要：目的探讨药物联合感统训练对高功能孤独症谱系障碍(ASD)儿童的疗效及对患儿血清脑源性神经营养因子水平的影响。方法选取2015年5月-2017年5月该院收治的高功能孤独症谱系障碍(HFA)儿童60例,按照治疗方式的差异随机分为研究组和对照组,对照组患者给予托莫西汀进行药物治疗,研究组患者在进行药物治疗的基础上,联合采取感统训练进行综合治疗,研究对比两组患者临床疗效以及两组患者血清脑源性神经营养因子水平的差异。结果治疗后两组患者的掩饰性因子(L)、神经质因子(N)、内外倾因子(E)评分都有了一定程度的降低,其中研究组L、N、E评分下降程度较对照组更加明显(P<0. 05),治疗前后两组精神质因子(P)评分没有显著变化(P>0. 05);治疗前两组患者综合反应控制商数(FRCQ)、综合注意力商数(FAQ)评分未出现明显差异,治疗6个月后FRCQ和FAQ评分均有一定程度的降低,研究组患者视听整合连续执行能力改善情况优于对照组(P<0. 05);治疗前两组患者语言、自理、运动、交往以及感觉评分未出现明显差异,治疗6个月后各方面评分均出现一定程度的降低,研究组患者孤独症改善情况优于对照组(P<0. 05);治疗前两组患者注意缺陷评分以及多冲动评分未出现明显差异,治疗6个月后两方面评分均出现一定程度的降低,研究组患者注意缺陷障碍改善情况优于对照组(P<0. 05),治疗后研究组血清BDNF水平上升优于对照组(P<0. 05)。结论在对高功能孤独症谱系障碍儿童进行治疗的过程中,药物治疗联合感统训练治疗效果显著优于单纯使用药物治疗效果,具有临床推广价值。Objective To explore the curative effect of drug therapy combined with sensory integration training in treatment of children with high-functioning autism spectrum disorder (HFA) and the influence on serum brain-derived neurotrophic factor levels in children.Methods Sixty HFA children treated in Tianjin Children’s Hospital from May 2015 to May 2017 were selected and divided into study group and control group according to the difference of treatment methods. The patients in control group were treated with tomoxetine. The patients in study group were treated with tomoxetine combined with sensory integration training. The clinical effects and the levels of serum brain-derived neurotrophic factor in the two groups were compared. Results After treatment,the scores of dissimulation factor (L),nervousness factor (N),introversion and extroversion factors (E) in the two groups decreased to a certain extent. The decreasing degrees of L,N,and E scores in study group were statistically significantly larger than those in control group (P< 0. 05). There was no statistically significant difference in the score of psychoticism factor (P) between before and after treatment in the two groups (P>0. 05). Before treatment,there was no statistically significant difference in the scores of FRCQ and FAQ between the two groups,FRCQ and FAQ scores decreased to a certain extent at 6 months after treatment,the improvement of audiovisual integration continuous performance in study group was statistically significantly better than that in control group (P<0. 05). There was no statistically significant difference in the scores of language,self-care,exercise,social contact,and feeling before treatment between the two groups,after 6 months of treatment,the scores in all aspects decreased to a certain extent. The improvement of autism in study group was statistically significantly better than that in control group (P < 0. 05).There was no statistically significant difference in scores of attention deficit and impulse before treatment between the

关 键 词：药物治疗 感统训练 高功能孤独症谱系障碍 血清脑源性神经营养因子 

分 类 号：R749.94[医药卫生—神经病学与精神病学]