钠氢交换蛋白1与肿瘤耐药  

Advances of NHE1 in Tumor Chemoresistance

作　　者：陈琦[1,2] 池华茂 许文林[1] CHEN Qi;CHI Hua-Mao;XU Wen-Lin(Department of Breast Surgery,Fourth Affiliated Hospital of Jiangsu Universtty,Zhenjiang 212001,Jiangsu,China;Central Laboratory,Fourth Affiliated Hospital of Jiangsu Universtty, Zhenjiang 212001,Jiangsu,China)

机构地区：[1]江苏大学附属第四人民医院乳腺科,江苏镇江2120012 [2]江苏大学附属第四人民医院中心实验室,江苏镇江212001

出　　处：《中国生物化学与分子生物学报》2019年第1期13-18,共6页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家自然科学基金(No.81402165/81672913);江苏省自然科学基金(No.BK20141288/BK20171311);镇江市社会发展项目(No.SH2017016);镇江市卫生科技重点专项(No.SHW2016009)资助~~

摘　　要：化疗药物耐药逐渐成为肿瘤治疗的主要障碍。肿瘤耐药的发生机制主要包括药物的外排增加、DNA修复增强、凋亡受抑、上皮-间质转化以及肿瘤干细胞的存在。因此,迫切需要寻找新的生物标志物,通过逆转肿瘤的耐药性,从而增加化疗药物的疗效,以提高患者的总体生存率。钠氢交换蛋白(sodium-hydrogen exchanger 1, NHE1)在调控肿瘤细胞的增殖、凋亡和耐药中发挥重要作用,被认为是肿瘤治疗中调控耐药性的潜在靶标。本文简要介绍钠氢交换蛋白的结构和主要功能,重点阐述钠氢交换蛋白对肿瘤耐药的影响和调控机制,以及在肿瘤的发展、转移中的作用的研究进展。Chemotherapeutic drug resistance has gradually become a major obstacle to clinical cancer treatment. The mechanisms of tumor resistance include increased drug efflux, enhanced DNA repair, inhibition of apoptosis, epithelial-mesenchymal transformation, and emerging of cancer stem cells. Therefore, it is urgent to find new biomarkers to increase the efficacy of chemotherapeutical drugs and improve the overall survival rate by reversing the development of tumor resistance. Sodium-hydrogen exchanger 1(NHE1) plays an important role in the regulation of tumor cell proliferation, apoptosis, and drug resistance, which can be considered as one of the potential targets for drug resistance in cancer treatments. In this paper, we briefly introduce the structure and main functions of NHE1, and review the effects and regulatory mechanisms of NHE1 on tumor resistance, as well as the role of NHE1 in the development and metastasis of cancer.

关 键 词：钠氢交换蛋白1 肿瘤 耐药 调控机制 

分 类 号：R730[医药卫生—肿瘤]