Melanin/polydopamine-based nanomaterials for biomedical applications  

作　　者：Chao Qi Lian-Hua Fu Han Xu Tian-Fu Wang Jing Lin Peng Huang 

机构地区：[1]Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Carson International Cancer Center, Laboratory of Evolutionary Theranostics, School of Biomedical Engineering, Health Science Center, Shenzhen University [2]Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University

出　　处：《Science China Chemistry》2019年第2期162-188,共27页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China (51802202, 51703132, 51573096, 21807074);the Postdoctoral Science Foundation of China (2017M612727, 2018M633123);the National Postdoctoral Program for Innovative Talents (BX201600111);the Guangdong Province Natural Science Foundation of PhD Start-up Fund (2018A030310566, 2018A030310574);the Basic Research Program of Shenzhen (JCYJ20170412111100742, JCYJ20160422091238319)

摘　　要：The natural melanin is one kind of ubiquitous biological pigments, which is produced in melanosomes and widely distributed in living organisms. The synthetic melanin, often known as polydopamine(PDA), has similar chemical compositions and physical properties to natural melanin. In recent years, both natural melanin and PDA have aroused increased research interests in biomedical fields owing to their inherent biocompatibility, antioxidant activity, free-radical scavenging, metal ion chelation,strong near-infrared absorption and high photothermal conversion efficiency. Inspired by these fascinating properties, melanin and PDA have been widely used as building blocks for the construction of multifunctional nanoplatforms for various biomedical applications. This review focuses on the state-of-the-art progress in melanin/PDA-based nanomaterials, which covers from their preparation methods to biomedical applications including bioimaging, treatment, theranostics, antibacterial, UV/radiation protection, biosensor and tissue engineering. Moreover, the current trends and the future prospects of melanin/PDA-based nanomaterials are also discussed.The natural melanin is one kind of ubiquitous biological pigments, which is produced in melanosomes and widely distributed in living organisms. The synthetic melanin, often known as polydopamine(PDA), has similar chemical compositions and physical properties to natural melanin. In recent years, both natural melanin and PDA have aroused increased research interests in biomedical fields owing to their inherent biocompatibility, antioxidant activity, free-radical scavenging, metal ion chelation,strong near-infrared absorption and high photothermal conversion efficiency. Inspired by these fascinating properties, melanin and PDA have been widely used as building blocks for the construction of multifunctional nanoplatforms for various biomedical applications. This review focuses on the state-of-the-art progress in melanin/PDA-based nanomaterials, which covers from their preparation methods to biomedical applications including bioimaging, treatment, theranostics, antibacterial, UV/radiation protection, biosensor and tissue engineering. Moreover, the current trends and the future prospects of melanin/PDA-based nanomaterials are also discussed.

关 键 词：MELANIN POLYDOPAMINE NANOMATERIALS BIOMEDICAL applications 

分 类 号：O6[理学—化学]