Intercalated kaolinite as an emerging platform for cancer therapy  

作　　者：Yi Zhang Peng Huang Mei Long Song Liu Huaming Yang Shuwen Yuan Shi Chang 

机构地区：[1]Department of Inorganic Materials, School of Minerals Processing and Bioengineering, Central South University [2]Hunan Key Laboratory of Mineral Materials and Application, Central South University [3]Xiangya Hospital, Central South University [4]Institute of Chemical Biology and Nanomedicine, College of Chemistry and Chemical Engineering, Hunan University [5]Department of Radiology, The Second Xiangya Hospital, Central South University

出　　处：《Science China Chemistry》2019年第1期58-61,共4页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China(21878341,51804343,41572036,51225403);the Strategic Priority Research Program of Central South University(ZLXD2017005);the Natural Science Foundation of Hunan Province(2018JJ3670);the Key R&D Program of Hunan Province(2017GK2251);Hunan Provincial Science and Technology Project(2016RS2004,2015TP1006)

摘　　要：An innovative cancer therapy strategy regarding the interface engineering of kaolinite has been designed. The exposed silanol group facilitates more guest species with high dispersion on the supports. Mn_3O_4 magnetic nanoparticles are uniformly distributed on external surfaces of the Kaolin_(C12N)with the Al–O–Mn bond for the detection of the tumor microenvironment by T1-MRI; Doxorubicin(DOX) are loaded in the interlayer space with the electrostatic interaction for chemo-treating; and KI is coated on the outer layer of the nanocomposites based on the electrostatic interaction for thyroid cancer targeting. The synergetic effects and the treatment mechanism enhanced by the interface engineering, KI@DOX-Mn_3O_4-Kaolin_(C12N)can cause remarkably low cell viability(57%, 200 μg/mL), tumor shrinking(75%, 20 μg/kg), and accumulation into the tumor tissues. The novel kaolinite based drug delivery system is expected to incorporate imaging diagnosis, targeted therapy and drug delivery into one single system for postoperative residual thyroid cancer treatment and observation for metastasis of focal area.An innovative cancer therapy strategy regarding the interface engineering of kaolinite has been designed. The exposed silanol group facilitates more guest species with high dispersion on the supports. Mn_3O_4 magnetic nanoparticles are uniformly distributed on external surfaces of the Kaolin_(C12N)with the Al–O–Mn bond for the detection of the tumor microenvironment by T1-MRI; Doxorubicin(DOX) are loaded in the interlayer space with the electrostatic interaction for chemo-treating; and KI is coated on the outer layer of the nanocomposites based on the electrostatic interaction for thyroid cancer targeting. The synergetic effects and the treatment mechanism enhanced by the interface engineering, KI@DOX-Mn_3O_4-Kaolin_(C12N)can cause remarkably low cell viability(57%, 200 μg/mL), tumor shrinking(75%, 20 μg/kg), and accumulation into the tumor tissues. The novel kaolinite based drug delivery system is expected to incorporate imaging diagnosis, targeted therapy and drug delivery into one single system for postoperative residual thyroid cancer treatment and observation for metastasis of focal area.

关 键 词：KAOLINITE PILLARED DRUG delivery system THYROID cancer 

分 类 号：O6[理学—化学]