Significant Polymorphisms of Vitamin D Receptor Gene(rs2189480 and rs3847987) Related to the Risk of Type 2 Diabetes in Henan Rural Area  

作　　者：HAN Han ZHAO Ming Xu WANG Yan WANG Jun REN Bing Nan GE Hui Na WANG Teng SUN Bei Bei BA Yue LI Wen Jie 

机构地区：[1]Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University [2]Department of Environmental Hygiene, College of Public Health, Zhengzhou University [3]Department of Epidemiological, College of Public Health, Zhengzhou University

出　　处：《Biomedical and Environmental Sciences》2019年第1期58-62,共5页生物医学与环境科学（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China[81573151,81872626,and81573243];Science and Technology Foundation for Innovation Talent of Henan Province[154200510010];Dietary Nutrition Research and Education Foundation of Danone[DIC2013-06]

摘　　要：Type 2 diabetes mellitus (T2DM) accounts for 90% of all diabetes cases and results in severe complications. It is a multifactorial metabolic disorder that results from a combination of resistance to insulin action and an inadequate compensatory insulin secretory response. The interaction between multiple genetic and environmental determinants has been considered to contribute to the pathogenesis of T2DM[1].

关 键 词：VITAMIN D Type 2 diabetes MELLITUS (T2DM) INSULIN 

分 类 号：Q[生物学]