High Prevalence and Factors Contributing to Hyperhomocysteinemia, Folate Deficiency, and Vitamin B_(12) Deficiency among Healthy Adults in Shanghai, China  

作　　者：WANG Yu Heng YAN Qing Hua XU Ji Ying LI Xin Jian CHENG Min Na 

机构地区：[1]Shanghai Municipal Center for Disease Control and Prevention

出　　处：《Biomedical and Environmental Sciences》2019年第1期63-67,共5页生物医学与环境科学（英文版）

摘　　要：Elevated plasma or serum total homocysteine (tHcy) level has been established as a risk factor for cardiovascular disease[1], as well as dementia and cognitive decline[2]. Plasma or serum folate and vitamin B12 influence homocysteine (Hcy) metabolism as a co-substrate and cofactor respectively, so that low concentrations of folate and vitamin B12 are also associated with high Hcy levels[1]. However, not much information is available describing serum tHcy, folate, and vitamin B12 status in Shanghai adults, especially in a healthy population. Therefore, we hypothesize that low serum folate and vitamin B12 is associated with high Hcy in healthy adults in Shanghai. The aim of this study was to determine the status of serum tHcy, folate, and vitamin B12, and the prevalence and factors contributing to HHcy, folate deficiency, and vitamin B12 deficiency among healthy adults in Shanghai, China.

关 键 词：Cardiovascular disease Serum total HOMOCYSTEINE (tHcy) VITAMIN B12 

分 类 号：Q[生物学]