托烷司琼联合地塞米松对腹腔镜食管裂孔疝修补术患者术后恶心呕吐的影响  

Effect of tropisetron combined with dexamethasone on postoperative nausea and vomiting in patients undergoing laparoscopic esophageal hiatal hernia repair

作　　者：阿里木江.司马义 王晓丽[1] 徐桂萍[1] 唐冬梅[1] Alimujiang Simayi;Wang Xiaoli;Xu Guiping;Tang Dongmei(Department of Anesthesiology,People's Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830000,China)

机构地区：[1]新疆维吾尔自治区人民医院麻醉科,乌鲁木齐830000

出　　处：《中国医药》2019年第2期268-270,共3页China Medicine

基　　金：新疆维吾尔自治区自然科学基金(2017D01C144)~~

摘　　要：目的探讨托烷司琼联合地塞米松对腹腔镜食管裂孔疝修补术患者术后恶心呕吐(PONV)的影响。方法选择2016年6月至2018年1月在新疆维吾尔自治区人民医院行择期腹腔镜食管裂孔疝修补术的女性患者150例,完全随机分为地塞米松组、托烷司琼组和联合治疗组,各50例。患者均行全身麻醉,气管插管后5 min,地塞米松组静脉给予地塞米松5 mg;托烷司琼组静脉给予托烷司琼注射液5 mg;联合治疗组静脉给予托烷司琼5 mg和地塞米松5 mg。手术结束后24 h比较各组PONV发生情况和PONV视觉模拟评分。结果地塞米松组和托烷司琼组PONV发生率和PONV视觉模拟评分均明显高于联合治疗组[20. 0%(10/50)、12. 0%(6/50)比4. 0%(2/50),(3. 8±1. 1)、(3. 9±1. 1)分比(2. 4±0. 6)分],差异均有统计学意义(均P <0. 05),而地塞米松组与托烷司琼组比较差异均无统计学意义(均P> 0. 05)。结论托烷司琼联合地塞米松能有效降低腹腔镜食管裂孔疝修补术患者PONV发生率,是围术期减少PONV并发症较为理想的联合用药选择,效果优于单一用药。Objective To investigate the effect of tropisetron combined with dexamethasone on postoperative nausea and vomiting(PONV) in patients undergoing laparoscopic esophageal hiatal hernia repair. Methods A total of 150 female patients undergoing laparoscopic esophageal hiatal hernia repair in People′s Hospital of Xinjiang Uygur Autonomous Region from June 2016 to January 2018 were randomly divided into dexamethasone group, tropisetron group and combined treatment group, with 50 cases in each group. All patients had general anesthesia;5 minutes after tracheal intubation, the dexamethasone group was intravenously given 5 mg dexamethasone;the tropisetron group was intravenously given 5 mg tropisetron injection;the combined treatment group was intravenously given 5 mg tropisetron and 5 mg dexamethasone. Incidence of PONV and score of PONV Visual Analogue Scale were analyzed 24 h after operation. Results Incidence of PONV and score of PONV Visual Analogue Scale in the dexamethasone group and tropisetron group were significantly higher than those in the combined treatment group[20.0%(10/50),12.0%(6/50) vs 4.0%(2/50);(3.8±1.1),(3.9±1.1) vs (2.4±0.6)](P<0.05);there was no significant difference between the dexamethasone group and tropisetron group(P>0.05). Conclusion Tropisetron combined with dexamethasone can effectively reduce the incidence of PONV after laparoscopic esophageal hiatal hernia repair.

关 键 词：食管裂孔疝 托烷司琼 地塞米松 术后恶心呕吐 

分 类 号：R571[医药卫生—消化系统]