磷脂酰肌醇3-激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白通路对肺癌细胞放射后生物学行为变化影响的研究进展  

Influence of phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin pathway on biological behavior of lung cancer cells after radiotherapy

作　　者：代佩灵[1] 李文辉[1] 陈凯[2] 陈正庭 李蓉[1] 陈海霞[1] 曹轲 夏耀雄[1] 侯宇[1] 李岚[1] 王丽[1] 常莉[1] Dai Peiling;Li Wenhui;Chen Kai;Chen Zhengting;Li Rong;Chen Haixia;Cao Ke;Xia Yaoxiong;Hou Yu;Li Lan;Wang Li;Chang Li(Department of Radiotherapy,the Third Affiliated Hospital of Kunming Medical University,Yunnan Cancer Hospital, Kunming 650100,China;Department of Cardiothoracic Surgery,the 2nd Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medcial University,Wenzhou 325027,China)

机构地区：[1]昆明医科大学第三附属医院云南省肿瘤医院放疗科,昆明650100 [2]温州医科大学附属第二医院温州医科大学附属育英儿童医院心胸外科,325027

出　　处：《中国医药》2019年第1期139-142,共4页China Medicine

基　　金：国家自然科学基金(81560488);云南省卫生科技计划(2016NS085);云南省卫生和计划生育委员会医学后备人才培养计划(H-201624);云南省教育厅科学研究基金(20152090)~~

摘　　要：放疗是治疗肺癌的主要方式之一,尽管其方法和技术不断完善,放疗后的复发转移依旧存在。研究放疗后的肺癌细胞生物学行为变化对于阻止肺癌复发和转移至关重要。磷脂酰肌醇3-激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白(PI3K/AKT/mTOR)通路在肺癌细胞的增殖、转移、细胞转化、葡萄糖代谢、DNA修复和血管生成中起到重要作用。本文总结了放射后PI3K/AKT/mTOR通路对肺癌细胞的增殖、侵袭、转移、放疗敏感性和能量代谢等生物学行为变化的影响的有关研究进展。Radiotherapy is a main therapeutic strategy of lung cancer. Recurrence and metastasis after radiotherapy are essential problems. Biological characteristics and behavior of lung cancer cells influenced by radiotherapy are crucial to the recurrence and metastasis of lung cancer. Phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin(PI3K/AKT/mTOR) pathway plays an important role in tumor cell growth, proliferation, metastasis, cell transformation, glucose metabolism, DNA repair and angiogenesis. This paper summarized the function of PI3K/AKT/mTOR pathway in the changes of proliferation, invasion, metastasis, radiosensitivity and energy metabolism of lung cancer cells after radiotherapy.

关 键 词：肺癌细胞 放疗 磷脂酰肌醇3-激酶 蛋白激酶B 哺乳动物雷帕霉素靶蛋白 放射后生物学行为 

分 类 号：R735.2[医药卫生—肿瘤]