生熟白芥子不同配比三伏灸协定处方对皮肤起泡的影响  

A Clinical Study on the Effect of Different Formulations of Raw and Cooked Mustard Seedlings on the Blistering of Skin

作　　者：赖龙胜 苏美玲 施莹 李相良 王永[2] 金海鹏 Lai Longsheng;Su Meiling;Shi Ying;Li Xiangliang;Wang Yong;Jin Haipeng(Jiangtou Street Community Health Service Center of Huli District,Xiamen 361009,China;Department of Acupuncture and Moxibustion,Xiamen Hospital of Beijing University of Chinese Traditional Medicine,Fujian 361012,China)

机构地区：[1]厦门市湖里区江头街道社区卫生服务中心针灸科,福建厦门361009 [2]北京中医药大学厦门医院针灸康复科,福建厦门361012

出　　处：《亚太传统医药》2019年第1期143-146,共4页Asia-Pacific Traditional Medicine

基　　金：厦门市中医院院内课题(XMSZYY201611)

摘　　要：目的:观察生熟白芥子不同配比三伏灸协定处方对皮肤起泡的影响及对血清免疫球蛋白(IgG)和外周血嗜酸粒细胞计数(EOS)的影响。方法:选取93例健康志愿者作为研究对象,采用随机数字表法将其随机分为三组,即高配比组(生熟白芥子配比1∶1)、中配比组(生熟白芥子配比1∶2组)和低配比组(生熟白芥子配比1∶3),每组各31例。分别采用不同配比三伏灸协定处方对各组受试者进行穴位敷贴干预,观察各组受试者的皮肤起泡情况,及其对血清免疫球蛋白(IgG)和外周血嗜酸粒细胞计数(EOS)的影响。结果:皮肤反应比较:经干预后,高配比组皮肤反应积分最高,低配比组皮肤反应积分最低,高配比组总积分及红斑反应积分、水泡反应积分与中、低配比组比较差异均有统计学意义(P<0.05),中配比组与低配比组总积分及红斑反应积分、水泡反应积分比较差异无统计学意义(P>0.05)。免疫指标变化比较:经干预后,高配比组、中配比组的EOS、IgE、IgM含量较干预前降低,差异具有统计学意义(P<0.05);高配比组与中配比组的EOS、IgE、IgM干预后的含量,差异无统计学意义(P>0.05);低配比组EOS、IgE、IgM含量较干预前有所下降,但差异无统计学意义(P>0.05);高配比组、中配比组干预后EOS、IgE、IgM含量与低配比组相比降低,差异具有统计学意义(P<0.05)。高配比组、中配比组IgG、IgA含量较干预前升高,差异具有统计学意义(P<0.05);高配比组与中配比组IgG、IgA干预后的含量,差异无统计学意义(P>0.05);低配比组IgG、IgA含量较干预前有所升高,但差异无统计学意义(P>0.05);高配比组、中配比组干预后IgG、IgA含量与低配比组相比升高,差异具有统计学意义(P<0.05)。结论:三伏灸穴位贴敷的生熟白芥子配比应适当,生熟白芥子的最适比例为1∶2,具有疗效好、皮肤不良反应少、安全性高等优点,可供临床参考。Objective:To observe the effect of prescription prescriptions of raw and cooked white mustard on the blistering of skin and the effect on serum immunoglobulin(IgG)and peripheral blood eosinophil count(EOS).Methods:93 healthy volunteers were selected as study subjects.Using a random number table method,they were randomLy divided into 3 groups:a high-matching group(1∶1 for raw cooked mustard seeds),a medium-matched group(1∶2 group for raw mustard seeds),and a low-grade product.The ratio of the group(raw white mustard 1∶3 ratio),each group of 31 cases.The acupoint application was applied to each group of subjects using different prescriptions of three-fold moxibustion protocol.Each point was applied for 2 hours,applied once every 10 days,and 3 times for one course of treatment.After one course of treatment,the skin blistering of each group of subjects was observed,and its effect on serum immunoglobulin(IgG)and peripheral blood eosinophil count(EOS).Results:Comparison of skin reactions:After intervention,the skin response score was highest in the high-matching group,and the skin response score was lowest in the lowmatching group.The total scores in the high-matching group and the erythema response score,bubbling response score,and the middle and low ratio groups were different.All were statistically significant(P <0.05).There was no significant difference in total scores,erythema response scores,and blisters response scores in the middle-matched group and the low-matched group(P>0.05).②Comparison of changes in immune parameters:After intervention,the levels of EOS,IgE,and IgM in the high-matched group and the middle-matched group were lower than before the intervention,and the difference was statistically significant(P<0.05);the high-matched group and the middle-matched group were There was no significant difference in the content of EOS,IgE and IgM after intervention(P>0.05).The content of EOS,IgE and IgM in the low-matched group decreased compared with that before the intervention,but the difference was not

关 键 词：皮肤反应 起泡 免疫 三伏灸 穴位敷贴 白芥子 

分 类 号：R285[医药卫生—中药学]