湖北钟祥长寿老年人认知功能与APOE基因多态性和慢性疾病分析  

Associations of cognitive function with APOE gene polymorphism and chronic diseases among long-lived people in Zhongxiang City of Hubei Province

作　　者：檀春玲 于普林[2] 王桦[1] 叶光明[3] 章桂芬 李晨芳[1] 刘国栋[1] Tan Chunling;Yu Pulin;Wang Hua;Ye Guangming;Zhang Guifen;Li Chenfang;Liu Guodong(Department of Geriatrics, Zhongnan Hospital, Wuhan University, Wuhan 430071, China;Beijing Hospital, National Center of Gerontology, Beijing 100730, China;Department of Laboratory Medicine, Zhongnan Hospital, Wuhan University, Wuhan 430071, China)

机构地区：[1]武汉大学中南医院老年医学科,430071 [2]北京医院国家老年医学中心,100730 [3]武汉大学中南医院检验科,430071

出　　处：《中华老年医学杂志》2019年第2期204-208,共5页Chinese Journal of Geriatrics

基　　金：湖北省老龄办重点项目研究基金(HBLLB2017004).

摘　　要：目的调查分析湖北省钟祥长寿老年人的认知功能与APOE基因多态性和慢性病的相关性。方法由经过统一培训的工作人员以面对面的形式调查湖北钟祥110例长寿老年人(≥90岁)认知功能,根据简易智力状态检查量表(MMSE)分数将其分为无痴呆风险组与痴呆风险组,分析比较两组长寿老年人一般人口学特征、日常生活能力、抑郁状态、营养状况、APOE基因和慢性病与痴呆风险的相关性。结果110例长寿老年人MMSE平均得分(22.3±4.8)分,18例长寿老年人存在痴呆风险,占总人数16.4%,92例无痴呆风险,占总人数83.6%。长寿老年人痴呆的发生风险与日常生活能力、抑郁状态、营养状况、跌倒呈明显相关性(均P<0.05);APOE基因检测显示携带ε4/ε3基因在痴呆风险组为8例,无痴呆风险组16例,前者比后者含ε4/ε3基因型频率高,两者差异有统计学意义(44.4%比17.4%,χ^2=6.46,P<0.05),前者比后者ε4等位基因频率更高,但两者差异无统计学意义(22.2%比10.3%,χ^2=3.96,P=0.055);长寿老年人常见慢性病为高血压86例(78.2%)、听力下降72例(65.5%)、高脂血症56例(50.9%)、贫血43例(39.1%),视力下降39例(35.5%)、慢性肾脏病25例(22.7%)、心脏疾病和骨关节病各18例(16.4%),痴呆风险与所患慢性病无明显相关性(P>0.05)。结论钟祥长寿老年人日常生活能力越强、心理状态越积极、营养状况越好,其认知功能越强,痴呆风险与APOE基因ε4/ε3型相关,与慢性病无关。ObjectiveTo investigate the associations of cognitive function with apolipoprotein E(APOE)gene polymorphism and chronic diseases among long-lived people in Zhongxiang City of Hubei Province. MethodsA total of 110 long-lived elderly residents aged 90 years and over were collected.Their cognitive function was determined face-to-face using questionnaires by trained interviewers.According to mini-mental state examination(MMSE)scores, subjects were divided into a no dementia risk group and a high dementia risk group.General demographic characteristics, activities of daily living, depression state and nutrition status were compared between the two groups.Correlations of dementia with APOE gene polymorphism and chronic diseases were analyzed. ResultsThe average MMSE score was 22.3±4.8.Among the 110 long-lived people, 18 cases had a high risk for dementia, accounting for 16.4%, and 92 cases had no risk of dementia, accounting for 83.6%.The risk of dementia in long-lived elderly people was correlated with activities of daily living, mental state, nutritional status and falls(all P<0.05). There were 8 cases with the APOE gene ε4/ε3 genotype in the high dementia risk group and 16 cases with the APOE gene ε4/ε3 genotype in the no dementia risk group, with the former group showing a higher frequency of the APOE ε4/ε3 genotype(44.4% vs.17.4%, χ^2=6.46, P<0.05). The former group also seemed to have a higher APOE ε4 frequency, but the difference was not statistically significant(22.2% vs.10.3%, χ^2=3.96, P=0.055). Chronic diseases prevalent in the long-lived people were hypertension(86 cases, 78.2%), hearing loss(72 cases, 65.5%), hyperlipidemia(56 cases, 50.9%), anemia(43 cases, 39.1%), impaired vision(39 cases, 35.5%), chronic kidney diseases(25 cases, 22.7%), chronic heart diseases(18 cases, 16.4%)and osteoarthritis(18 cases, 16.4%). No correlation was found between the risk of dementia and chronic diseases(P>0.05). ConclusionsCognitive function is highly correlated with activities of daily living, mental state and

关 键 词：长寿 认知功能 APOE基因 慢性病 

分 类 号：R749.1[医药卫生—神经病学与精神病学]