OPG/RANKL/RANK系统在肿瘤骨转移中的作用  

The function of OPG/RANKL/RANK system in tumor bone metastasis

作　　者：苏屿[1] 周晓君[1] 黄涛[1] Su Yu;Zhou Xiaojun;Huang Tao(Department of Laboratory Medicine,Hainan General Hospital,Haikou 570311,China)

机构地区：[1]海南省人民医院检验科,海口570311

出　　处：《中华检验医学杂志》2019年第1期14-17,共4页Chinese Journal of Laboratory Medicine

基　　金：海南省自然科学基金(309104).

摘　　要：肿瘤骨转移是肿瘤治疗失败的主要原因之一,然而肿瘤骨转移是一个复杂的过程,发生发展机制尚未明确。近期研究表明,骨护素/核因子κB受体活化因子配体/核因子κB受体活化因子系统在肿瘤骨转移发生发展过程中具有重要作用。本文将就其生物学功能、调节骨微环境、分析检测方法和肿瘤治疗等方面进行阐述。Tumor bone metastasis is one of the main causes of treatment failure in tumor.Since tumor bone metastasis is a complex process,the exact etiopathogenesis of tumor bone metastasis has not been clarified.Recent studies demonstrated that osteoprotegerin/receptor activator of NF-κB ligand/receptor activator of NF-κB (OPG/RANKL/RANK)system plays an important role during the development and progression of tumor bone metastasis.In this review,the research progress of OPG/RANKL/RANK system, including biological functions,the bone microenvironment regulation,the detection method,the diagnosis and treatment of tumor will be summerized.

关 键 词：肿瘤转移 骨肿瘤 骨保护素 RANK配体 核因子ΚB受体活化因子 

分 类 号：R73-37[医药卫生—肿瘤]