肠易激综合征相关致病因素研究进展  

Progress in research on pathogenic factors of irritable bowel syndrome

作　　者：包玲珊 余颖聪 Bao Lingshan;Yu Yingcong(Wenzhou Medical University,the Third Clinical College of Wenzhou People's Hospital,Wenzhou Zhejiang 325000 China)

机构地区：[1]温州医科大学温州市第三临床学院温州市人民医院,浙江温州325000

出　　处：《医药前沿》2018年第34期9-12,共4页Journal of Frontiers of Medicine

基　　金：温州市科教局合作处课题资助,编号H20150004.

摘　　要：肠易激综合征(irritable bowel syndrome,IBS)是一种常见的肠道功能紊乱性疾病,以腹痛、腹胀、排便习惯和(或)大便性状改变为主要临床表现。中国人群IBS总患病率为6.5%,且女性患病率高于男性(8.1%vs 6.8%)。IBS的发病机制较为复杂,尚没有一种病因和发病机制可以解释IBS的所有临床表现。多项研究证实其可能与遗传、性别、内脏高敏性、脑肠肽、感染、饮食和精神心理因素等有关。本文就其病因和发病机制的最新进展进行综述。Irritable bowel syndrome (IBS)is a common disorder of intestinal function,characterized by abdominal pain,abdominal distension,defecation habits and/or changes in bowel behavior.The overall incidence of IBS in Chinese population is 6.5%,and the prevalence rate of women is higher than that of men (8.1% vs.6.8%).The pathogenesis of IBS is complex,and there is no single etiology and pathogenesis that can explain all the clinical manifestations of IBS.A number of studies have confirmed that it may be related to genetics,gender,visceral hypersensitivity,brain and intestinal peptide,infection,diet and psychosocial factors.This paper reviews the recent progress of its etiology and pathogenesis.

关 键 词：肠易激综合征 致病因素 发病机制 研究 

分 类 号：R572[医药卫生—消化系统]