On the low reproducibility of cancer studies  

作　　者：Haijun Wen Hurng-Yi Wang Xionglei He Chung-I Wu 

机构地区：[1]State Key Laboratory of Biocontrol,College of Ecology and Evolution,Sun Yat-Sen University [2]Graduate Institute of Clinical Medicine and Hepatitis Research Center,Taiwan University and Hospital [3]Department of Ecology and Evolution,University of Chicago

出　　处：《National Science Review》2018年第5期619-624,共6页国家科学评论（英文版）

基　　金：supported by the National Nat ural Science Foundation of China (31730046 91731302, 91731301);the National Basic Research Program (973 Program) of China (2014CB542006 and 2014CB542005);the 985 Project (33000-18821105);the StrategicPriority Research Program of the Chinese Academy of Sciences (XDB13040300)

摘　　要：INTRODUCTION Previous reports have suggested that close to 90% of cancer biology publications are irreproducible.The low number has recently been corroborated by five detailed replication studies in eLife,which have been commented on in Nature (Replication studies offer much more than technical details. Nature 2017;541:259-60).While the irreproducibility is often attributed to human factors,which are remediable,the reason might be biological and the irreproducibility is intrinsic to such studies. The low reproducibility,reflecting the diversity in the evolutionary pathways of tumourigenesis,will likely significantly impact clinical strategies.

关 键 词：CANCER STUDIES CANCER BIOLOGY PUBLICATIONS irreproducibility 

分 类 号：N[自然科学总论]