线粒体内质网结构偶联介导的线粒体Ca^(2+)摄取及其与肿瘤发生关系研究进展  

Progress in the Study of the Relationship between Mitochondria Ca^(2+) Intake Mediated by Mitochondria-Associated Endoplasmic Reticulum Membranes and Tumorigenesis

作　　者：朱子建 张嘉煜 孙夏承 郭欣 季乐乐[2] 黄启超[2] Zhu Zijian;Zhang Jiayu;Sun Xiacheng;Guo Xin;Ji Lele;Huang Qichao(The Fourth Brigade,School of Basic Medical Sciences,The Fourth Military Medical University,Xi'an 710032,China;preclinical Medical Teaching Experiment Center of Fourth Military Medical University,Xi'an 710032,China;First Affiliated Hospital Neurology,The Fourth Military Medical University,Xi'an 710032,China)

机构地区：[1]第四军医大学基础医学院四大队,西安710032 [2]第四军医大学基础医学院教学实验中心,西安710032 [3]第四军医大学第一附属医院神经内科,西安710032

出　　处：《中国细胞生物学学报》2018年第12期2072-2076,共5页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:81772935;81400197)资助的课题~~

摘　　要：线粒体内质网结构偶联(mitochondria-associated endoplasmic reticulum membranes,MAMs)是线粒体外膜与内质网膜间形成的、具有稳定间距的相互作用膜结构,在介导两细胞器间的物质和信息传递中发挥关键作用。研究表明, MAMs上分布有大量Ca^(2+)转运通道及相关调控蛋白,可精细调控线粒体Ca^(2+)稳态及ATP生成、细胞凋亡等一系列重要细胞生命活动。进一步研究还发现,MAMs上富集了大量肿瘤相关分子,因此,其参与恶性肿瘤发生的作用机制迅速成为肿瘤基础研究的热点。该文围绕MAMs对线粒体Ca^(2+)摄取及肿瘤发生调控的最新研究进展予以综述,旨在为进一步理解肿瘤发病机制提供新的思路和依据。Mitochondria-associated endoplasmic reticulum membranes(MAMs) are regions of the endoplasmic reticulum(ER) tethered to mitochondria, which play a key role in mediating material transfer and signal transduction between the two organelles. Recent studies have demonstrated that a large number of Ca2+transporter proteins and their regulatory proteins are located on MAMs, which can finely regulate a series of important cellular activities such as mitochondrial Ca2+ homeostasis, ATP production and cell apoptosis. Further studies also imply that MAMs are also enriched with many oncogenic proteins and tumor suppressor proteins, which are closely related to the regulation of Ca2+ transport. Therefore, the role of MAMs in tumorigenesis has received extensive attention. In this review, we focus on the regulatory mechanisms of Ca2+ transport mediated by MAMs and their role in tumorigenesis, aiming to acquire the new insight to further understanding the pathogenesis of tumors.

关 键 词：线粒体 线粒体内质网结构偶联 Ca^2+信号 肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]