基于“微生物-脑-肠轴”观察理肠汤对脾虚湿困型溃疡性结肠炎患者的作用  

Observation of the effect of Lichang decoction on spleen-deficiency and dampnesstype ulcerative colitis patients based on “microbial-brain-intestinal axis”

作　　者：谢伟昌[1] 姜小艳[2] 张竞超[1] 李健[1] 郭绍举[1] 黄明河[1] 黄彬[1] XIE Wei-chang;JIANG Xiao-yan;ZHANG Jing-chao;Li Jian;GUO Shao-ju;HUANG Ming-He;HUANG Bin(Department of Digestive,Shenzhen Hospital of Traditional Chinese Medicine,Shenzhen 518033,China;The Fourth Clinical Medical Department of Guangzhou University of Chinese Medicine,Shenzhen 518033,China)

机构地区：[1]深圳市中医院脾胃病科,广东深圳518033 [2]广州中医药大学第四临床医学院,广东深圳518033

出　　处：《中国中西医结合消化杂志》2018年第12期1013-1017,共5页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：国家中医药管理局全国名老中医药专家传承工作室建设项目(国中医药人教函[2018]134号)

摘　　要：[目的]探讨理肠汤通过"微生物-脑-肠轴"对溃疡性结肠炎(UC)患者的作用。[方法 ]治疗组以理肠汤联合柳氮胺吡啶肠溶片,单纯服用柳氮磺胺吡啶肠溶片为对照组,干预脾虚湿困型UC患者,对比2组患者肠道微生态、血清脑肠肽、短链脂肪酸的改善情况。并对比患者结肠镜下黏膜评分的改善程度。[结果]治疗组在双歧杆菌、乳杆菌、酵母菌的改善方面明显优于对照组(P<0.05);对SP、SS、乙酸、丙酸的调节优于对照组(P<0.05);对患者肠镜下黏膜变脆易损及黏膜损害改善也明显优于对照组(P<0.05)。且在治疗过程中未发现临床不良事件的发生。[结论]理肠汤对脾虚湿困型UC患者安全有效。[Objective]To investigate the effect of Lichang decoction on patients with ulcerative colitis(UC)through " microbial-brain-gut axis".[Methods]The treatment group was treated with Lichang decoction combined with sulfasalazine enteric-coated tablets,and the single administration of salazylaminopyridine enterolysis tablets was used as the control group to intervene in wet-trapped UC patients with spleen deficiency,the improvement of intestinal microecology,serum brain-gut peptide and short-chain fatty acid in the two groups were compared,and the degree of improvement of the colonic mucosal score in patients were compared.[Results]The treatment group was significantly better than the control group in the improvement of Bifidobacterium,Lactobacillus and Yeast(P<0.05).The regulation of SP,SS,acetic acid and propionic acid was better than that of the control group(P<0.05).The mucosal embrittlement and mucosal damage of the patients under the colonoscopy was also significantly better than the control group(P<0.05).No clinical adverse events were found during the treatment.[Conclusion]Lichang decoction is safe and effective for patients for spleen-deficiency and dampness-type UC patients.

关 键 词：理肠汤 溃疡性结肠炎 肠道微生态 脑肠肽 

分 类 号：R574.62[医药卫生—消化系统]