A novel mutation in 5'-UTR of Makorin ring finger 3 gene associated with the familial precocious puberty  

作　　者：Wenli Lu Junqi Wang Chuanyin Li Manqing Sun Ronggui Hu Wei Wang 

机构地区：[1]Department of Pediatrics,Ruijin Hospital Affiliated with Shanghai Jiao Tong University,Shanghai 200025,China [2]State Key Laboratory of Molecular Biology,CAS Center for Excellence in Molecular Cell Science,Innovation Center for Cell Signaling Network,Shanghai Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,Shanghai 200031,China [3]University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Acta Biochimica et Biophysica Sinica》2018年第12期1291-1293,共3页生物化学与生物物理学报（英文版）

摘　　要：Central precocious puberty (CPP)is one of the most common and complex problems in clinical pediatric endocrinology practice. Currently,CPP is believed to result from complex interactions between genetic,endocrinal,nutritional,and environmental factors. Most CPP cases are commonly associated with an early activation of hypothalamic-pituitary-gonadal (HPG)axis followed by overproduction and release of GnRH from hypothalamus.

关 键 词：hypothalamic-pituitary-gonadal Central PRECOCIOUS puberty 

分 类 号：Q[生物学]