幽门螺杆菌相关胃癌与多胺代谢  

Helicobacter Pylori related gastric cancer and polyamine metabolism

作　　者：李论[1] 陈鹏飞 朱俊垚 王艳林[1] LI Lun;CHEN Pengfei;ZHU Junyao;WANG Yanlin(Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy,Three Gorges University Medical College, Yichnang 443002,china)

机构地区：[1]三峡大学医学院,肿瘤微环境与免疫治疗湖北省重点实验室,宜昌443002

出　　处：《生命的化学》2018年第6期787-791,共5页Chemistry of Life

基　　金：国家自然科学基金项目(81372265)

摘　　要：幽门螺旋杆菌(Helicobacter pylori, H. pylori)选择性地在人的胃黏膜中定植,是引发胃癌的最强危险因素之一。多胺是一类广泛存在于真核细胞中带高密度正电荷的烷基类小分子化合物,参与细胞增殖、分化、凋亡等重要的生理过程,多种疾病的发生发展与多胺代谢紊乱相关。近期研究发现,H.pylori感染能诱导宿主胃黏膜上皮细胞和巨噬细胞中多胺代谢异常。特别是该菌对多胺代谢途径中的关键酶ARG2(arginase 2,精氨酸酶2)、ODC(ornithine decarboxylase,鸟氨酸脱羧酶)和SMO(soermine oxidase,精胺氧化酶)的激活作用,与H. pylori免疫逃逸,慢性炎症维持、DNA损伤和胃癌的发生发展密切相关,提示多胺代谢途径可能成为H. pylori相关胃癌防治的新靶点。Helicobacter pylori(H. pylori) which selectively colonize in human gastric mucosa is one of the strongest risk factors for gastric cancer. Polyamines are a class of small alkyl compounds with high density positive charge in eukaryotic cells and involved in cell proliferation, differentiation, apoptosis and other important physiological processes. Disorder of polyamine metabolism is also related to the development of many diseases. Recent studies have shown that H. pylori infection can induce metabolic abnormality of polyamines in the host gastric epithelial cells and macrophages. In particular, the activation of ARG2, ODC and SMO(the key enzymes in polyamine metabolic pathway) induced by H. pylori is closely related to the immune escape of H. pylori, the maintenance of chronic inflammation, the damage of DNA and the development of gastric cancer, which suggests that the polyamine metabolic pathway may be a new target for the prevention and treatment of H. pylori-related gastric cancer.

关 键 词：幽门螺杆菌 精氨酸酶 鸟氨酸脱羧酶 精胺氧化酶 胃癌 

分 类 号：R735.2[医药卫生—肿瘤]