TRPV4通道及其与疾病关系的研究进展  

Research progress of TRPV4 channel and its relationship with diseases

作　　者：吴静 程全艺 杨梦成 张世忠[1] WU Jing;YANG Mengcheng;ZHANG Shizhong(Medical College of China Three Gorges University,Y/chang 443002,China)

机构地区：[1]三峡大学医学院,宜昌443002

出　　处：《生命的化学》2018年第6期809-814,共6页Chemistry of Life

基　　金：国家自然科学基金项目(30872716);湖北省自然科学基金(2015CFB288);湖北省卫生厅科研项目(WJ2015MB171)

摘　　要：瞬时受体电位香草素受体4型通道蛋白(transient receptor potential vanilloid 4, TRPV4)是瞬时受体电位离子通道的成员之一,属于非选择性阳离子通道。TRPV4广泛分布于心、大脑、肾、肝、肺、胰腺、卵巢、骨组织以及皮肤表面,可被机械刺激、低渗透压、佛波酯衍生物等理化刺激激活,并参与体内多种疾病的病理生理过程。文章主要介绍了TRPV4的结构特点、生理功能及其与心血管、呼吸、消化、运动及肿瘤等相关疾病的关系的最新进展。The transient receptor potential vanilloid 4(TRPV4), belonging to a non-selective cation channel, is one of the transient receptor potential ion channel members. TRPV4 is widely distributed in the human heart, brain, kidney, liver, lung, pancreas, ovary, bone tissue, and skin surface. It can be activated by mechanical stimulation, low osmotic pressure, phorbol ester derivatives and other physicochemical stimuli, and participates in the pathophysiological processes of various diseases in human body. This article reviewed the latest progress in the structural features and physiological functions of TRPV4, and its relationship with various diseases, including cardiovascular, respiratory, digestive, exercise-related diseases and tumor.

关 键 词：TRPV4 心血管疾病 呼吸系统疾病 消化系统疾病 运动系统疾病 肿瘤 

分 类 号：R363[医药卫生—病理学]