NDUFS3在肿瘤发生发展中的作用及其机制  

The role and mechanism of NDUFS3 in tumorigenesis and development

作　　者：蒋露 易子寒[2] 朱月春 JIANG Lu;YI Zihan;ZHU Yuechun(Department of Biochemistry and Molecular Biology,Basic Medicalschool of Kunming Medical University, Kunming 650500,China;Yunnan Provincial Cancer Hospital,Kunming 650500,China)

机构地区：[1]昆明医科大学基础医学院,生物化学与分子生物学系,昆明650500 [2]云南省肿瘤医院,昆明650500

出　　处：《生命的化学》2018年第6期846-851,共6页Chemistry of Life

基　　金：国家自然科学基金项目(81760455,81460421,31660246);云南省应用基础研究项目[2017FE468(-072),2017FE468(-003),2018FE468(-001)];云南省教育厅科学研究基金项目(2017YJS080);云南省教育厅科学研究基金项目(2015J057);昆明医科大学研究生创新基金项目(2017S050)

摘　　要：NADH脱氢酶[泛醌]铁硫蛋白3(NADH dehydrogenase [ubiquinone] ferrithionein 3, NDUFS3)是线粒体复合体Ⅰ的核心亚基,直接参与呼吸链的电子传递的过程,在人类各组织器官中的表达水平高低不一。NDUFS3参与肿瘤的发生发展,与细胞活性氧ROS(reactive oxygen species)水平,三磷酸腺苷(adenosinetriphosphate, ATP)生成以及Warburg效应密切相关。本文综述了NDUFS3在肿瘤中的作用及其可能分子机制的研究进展。NADH dehydrogenase [ubiquinone] ferrithionein 3(NDUFS3), the core subunit of mitochondrial complex I, directly participates in the electron transport of the respiratory chain, and displays different expression level in human tissues and organs. In recent years, it has been found that NDUFS3 is involved in tumorigenesis and development, and is closely related to ROS level, energy production and Warburg effect in cells. This paper reviews the effect of NDUFS3 in tumor and its possible molecular mechanism.

关 键 词：NADH脱氢酶[泛醌]铁硫蛋白3 肿瘤 生物学表型 

分 类 号：R730.2[医药卫生—肿瘤]