血清Livin、IFN-γ水平在血管性痴呆患者中的变化及其临床意义  

The changes and its clinical significance of serum Livin,IFN-γin patients with vascular dementia

作　　者：郝美美[1] 李晨曦[1] Hao Meimei(Department of Neurology,Yan'an People's Hospital ,Yan'an 716000)

机构地区：[1]陕西省延安市人民医院神经内科,716000

出　　处：《卒中与神经疾病》2018年第6期668-671,680,共5页Stroke and Nervous Diseases

摘　　要：目的探讨凋亡抑制蛋白抗体(Livin)、干扰素-γ(interferon-γ,IFN-γ)水平在血管性痴呆患者中的变化及其临床意义。方法选取2016年1月-2018年1月本院神经内科住院部收治的血管性痴呆患者150例作为研究组,同期选取本院健康体检中心的体检健康者150例作为对照组,采用酶联免疫吸附试验(Enzyme-linked immunosorbent assay,ELISA)检测血清Livin,IFN-γ水平,参照简易精神状态量表(Minimental State Examination,MMSE)标准评定病情程度,参照美国国立卫生研究院卒中量表(National Institute of Health Stroke Scale,NIHSS)标准评定神经功能缺损程度,参照日常生活活动量表(activities of daily living scale,ADL)标准评定预后状况。结果研究组血清Livin水平明显低于对照组,血清IFN-γ水平明显高于对照组(P<0.05)。随着病情程度与神经功能缺损程度的加重,血清Livin水平呈逐渐降低的趋势,血清IFN-γ水平呈逐渐增高的趋势(P<0.05)。随着预后状况越来越差,血清Livin水平呈逐渐降低的趋势,血清IFN-γ水平呈逐渐增高的趋势(P<0.05)。结论血管性痴呆患者血清Livin水平明显降低,IFN-γ水平明显升高,且上述指标的改变幅度在指导病情程度、神经功能缺损程度与预后状况的评价中具有重要的意义。Objective To study the changes and its clinical significance of serum Livin,interferon-γ (IFN-γ) in patients with vascular dementia.Methods 150 cases of patients with vascular dementia treated from neurology inpatient department of our hospital in the period from January 2016 to January 2018 were selected as study group,at the same time 150 cases of healthy check-up from our physical examination center were selected as control group.The serum Livin,IFN-γlevels were detected by using enzyme-linked immunosorbent assay (ELISA) method,the illness degree was evaluated by Mini-mental State Examination (MMSE) standard,nerve function defect was evaluated by National Institute of Health Stroke Scale (NIHSS) standard,prognosis was evaluated by activities of daily living Scale (ADL) standard.Results The serum Livin level of study group was obviously lower than that of control group,serum IFN-γlevel of study group was significantly higher than that of control group (P<0.05).As the illness degree and nerve function defect were aggravating,serum Livin level were gradually reduced trend,serum IFN-γlevel were gradually increased trend (P<0.05).As the prognosis was more worse,serum Livin level were gradually reduced trend,serum IFN-γlevel were gradually increased trend (P<0.05).Conclusion The serum Livin level was significantly lower,and serum IFN-γlevel was significantly increased in patients with vascular dementia,the change range of above parameters was great importance in guiding of evaluating illness degree,nerve function defect and prognosis.

关 键 词：血管性痴呆 凋亡抑制蛋白抗体 干扰素-Γ 

分 类 号：R742[医药卫生—神经病学与精神病学]