中西药物联用安全性评价——“征靶关联法”的探索建立  

The Safety Evaluation Method of Herb-Drug Combination: Manifestation-Target Alliance

作　　者：郑蕊 陈诗琪[1] 商洪才[1] Zheng Rui;Chen Shiqi;Shang Hongcai(Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China)

机构地区：[1]北京中医药大学东直门医院,北京100700

出　　处：《世界科学技术-中医药现代化》2018年第10期1734-1738,共5页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：中共中央组织部第二批国家"万人计划"(2016)经费资助项目(W02020052);第二批国家高层次人才特殊支持计划领军人才;负责人:商洪才

摘　　要：中西药联合应用越来越普遍。而其安全性评价是一个复杂的评价体系。本文对2008年-2018年期间Pubmed数据库进行分析,总结中西药联合应用安全性评价特点如下:(1)真实世界中暴露安全性问题(2)联用情况复杂,评价难度高。现有安全性评价方法如文献归纳法、前瞻性试验、问卷调查等,虽然从不同角度进行了安全性评价,但仍缺乏更全面合理的安全性评价方法。本团队尝试提出"征靶关联法"—临床多元证据体总结不良反应特征、网络靶标分析作用靶点,使临床特征与靶点机制相关联,为临床安全性评价实践提供更合理的方法学支持。The herb-drug combination is becoming more and more common. The safety evaluation method is a complex evaluation system. This paper analyzed Pubmed database from 2008 to 2018, and summarized the characteristics of safety evaluation method, and the characteristics are listed as below:(1) Exposure safety issues in real world;(2) The combination use is complex and difficult to evaluate. There are the existing safety assessment methods including literature induction, prospective test, questionnaire survey, etc. Although safety evaluation has been carried out from different angles, there is still a lack of comprehensive and reasonable safety evaluation method. The team tried to combine clinical phenotype and mechanism characteristics to provide more reasonable methodological support for clinical safety evaluation.

关 键 词：中西药联合应用 安全性评价方法 网络靶标分析 临床特征 机制 

分 类 号：R287[医药卫生—中药学]