生殖道感染与宫颈癌及宫颈癌前病变的相关性研究  

Study on the Relationship between Reproductive Tract Infection and Cervical Cancer and Cervical Precancerous Lesions

作　　者：顾卓伟[1] 邱丽华[1] 高华[1] 洪祖蓓[1] 顾李颖[1] 狄文[1] GU Zhuo-wei;QIU Li-hua;GAO Hua;HONG Zu-bei;GU Li-ying;DI Wen(Department of Obstetrics and Gynecology,Ren Ji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai Key Laboratory of Gynecologic Oncology,Ren Ji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai,200127,China)

机构地区：[1]上海交通大学医学院附属仁济医院上海市妇科肿瘤重点实验室,上海200127

出　　处：《现代生物医学进展》2018年第23期4439-4442,共4页Progress in Modern Biomedicine

基　　金：上海交通大学"医工交叉研究基金"项目(YG2017MS54);上海市重中之重临床重点学科--妇产科学研究项目(2017ZZ02016)

摘　　要：目的:探讨生殖道感染与宫颈癌、宫颈癌前病变的相关性及危险因素分析。方法:选取我院收治的185例宫颈癌及宫颈癌前病变患者和同期206例健康体检者分为两组,对人乳头瘤病毒(HPV)、沙眼衣原体(CT)、细菌性阴道病(BV)、阴道滴虫进行检测,观察分析相应病原微生物导致的生殖道感染与宫颈癌及宫颈癌前病变的关系,同时根据HPV不同基因型在宫颈癌及宫颈癌前病变中的致癌作用和程度,判定危险程度。结果:宫颈癌及宫颈癌前病变患者上述指标感染检出率明显高于对照组,差异具有统计学意义(P=0.000、0.001、0.000、0.037),其中高危HPV感染率随宫颈上皮内瘤变级别的升高而呈明显上升趋势,CINⅠ～Ⅲ级感染率分别为57.1%、78.6%和82.9%,宫颈癌感染率最高达91.1%,高危HPV为高危因素。结论:生殖道HPV、CT、BV、滴虫感染与宫颈癌及CIN存在必然或一定相关性,加强对妇女生殖道病原体感染的重视和检测对防治宫颈癌及CIN具有积极意义。Objective: To investigate the relationship between genital tract infection and cervical cancer, Cervical precancerous lesions and risk factors. Methods: A total of 185 cases of cervical cancer and Cervical precancerous lesions patients and 206 cases of healthy subjects in our hospital were divided into two groups. The human papilloma virus(HPV), Chlamydia trachomatis(CT), bacterial vaginosis(BV) and trichomonas vaginalis were detected and observed. The correlation between genital tract infection and cervical cancer and CIN was analyzed.At the same time, according to the different HPV genotypes in cervical cancer and cervical precancerous lesions in the carcinogenic effect and degree, determine the degree of risk. Results: The infection rate of HPV, CT, BV, trichomonas in patients of cervical cancer and Cervical precancerous lesions significantly higher than the control group, the difference was statistically significant(P=0.000, 0.001, 0.000, 0.037). The infection rate of high-risk HPV increasedwith the level of cervical intraepithelial neoplasia and cervical cancer significantly increased. The infection rates of CIN I to III were 57.1%, 78.6% and 82.9%, respectively. The infection rate of cervical cancer was up to 91.1%. High-risk HPV was the high risk factor. Conclusion: Genital tract infection of HPV, CT, BV and trichomonas exists the correlation with cervical cancer and Cervical precancerous lesions.To strengthen the attention and detection of pathogens in the genital tract of women has a positive significance for the prevention and treatment of cervical cancer and CIN.

关 键 词：生殖道感染 宫颈癌 宫颈癌前病变 人乳头瘤病毒 衣原体 

分 类 号：R737.33[医药卫生—肿瘤]