头颅局部亚低温联合醒脑静对急性脑出血的治疗效果  

Clinical effect of brain-located mild hypothermia therapy combined with Xingnaojing injection on acute cerebral hemorrhage and its effect on cognitive function

作　　者：沈凤娟 张建玲[1] 姚静 Shen Fengjuan;Zhang Jianling;Yao Jing(Department of EICU,Zoueheng People's Hospital,Zoucheng 273500,China)

机构地区：[1]邹城市人民医院EICU,山东邹城273500 [2]济宁医学院基础医学院药理学教研室

出　　处：《中国临床实用医学》2018年第6期25-28,共4页China Clinical Practical Medicine

摘　　要：目的探讨头颅局部亚低温联合醒脑静对急性脑出血的治疗效果及认知功能的影响。方法选取2016年5月至2018年5月邹城市人民医院EICU收治的80例急性脑出血患者,采用随机数表法随机分为物理治疗组与联合治疗组,每组40例,物理治疗组给予头颅局部亚低温治疗,联合治疗组在物理治疗组基础上加用醒脑静注射液,比较两组患者的治疗效果及认知功能变化。结果两组患者治疗前脑水肿体积及脑血肿体积比较,差异无统计学意义(P>0.05);治疗后,联合治疗组脑水肿体积[(8.94±2.90)ml]与脑血肿体积[(6.21±2.11)ml]较物理治疗组[(13.67±4.01)ml、(9.93±1.77)ml]改善显著,差异有统计学意义(P<0.05)。治疗后,联合治疗组NHISS评分[(8.12±2.93)分]较物理治疗组[(12.39±3.27)分]低,MMSE评分[(57.21±6.14)分]较物理治疗组[(23.67±5.01)分]高,差异有统计学意义(P<0.05)。治疗后,联合治疗组内皮素水平[(51.43±5.21)pg/ml]较物理治疗组[(67.89±6.12)pg/ml]低,且NO水平[(56.79±4.21)μmol/L]较物理治疗组[(42.12±5.26)μmol/L]高,差异有统计学意义(P<0.05)。结论头颅局部亚低温联合醒脑静治疗急性脑出血的临床效果显著,能够改善患者的认知功能,且安全可靠。Objective To investigate the effect of mild hypothermia combined with Xingnaojing on the treatment and cognitive function of acute cerebral hemorrhage.Methods A retrospective study was performed on 80 cases of patients with acute cerebral hemorrhage who were admitted in EICU from May 2016 to May 2018.Patients were randomly divided into the physiotherapy group and the combined treatment group,with 40 cases in each group.Patients in the physiotherapy group were treated with brain-located mild hypothermia therapy,and the patients of the combined treatment group were treated with Xingnaojing injection on the basis of treatment in physiotherapy group.The therapeutic effect and cognitive function changes of the two groups were compared.Results There was no statistically significant difference in the volume of anterior cerebral edema and cerebral hematoma between the two groups(P>0.05).After treatment,the combined treatment group showed significant improvement in cerebral edema volume[(8.94±2.90)ml]and cerebral hematoma volume[(6.21±2.11)ml]compared with the physical treatment group[(13.67±4.01)ml and(9.93±1.77)ml],with statistically significant difference(P<0.05).After treatment,NHISS score in the combined treatment group(8.12±2.93)was lower than that in the physical therapy group(12.39±3.27),and MMSE score(57.21±6.14)was higher than that in the physical therapy group(23.67±5.01),(P<0.05).After treatment,endothelin levels[(51.43±5.21)pg/ml]in the combined treatment group were lower than those in the physiotherapy group[(67.89±6.12)pg/ml],and NO levels[(56.79±4.21)μmol/L]were higher than those in the physiotherapy group[(42.12±5.26)μmol/L],(P<0.05).Conclusion The clinical effect of mild hypothermia combined with Xingnaojing in the treatment of acute cerebral hemorrhage is significant,which can improve the cognitive function of patients and is safe and reliable.

关 键 词：头颅局部亚低温 醒脑静注射液 急性脑出血 临床效果 认知功能 

分 类 号：R74[医药卫生—神经病学与精神病学]