血清感染因子与NT-proBNP在肺癌患者围手术期的改变研究  

Changes of serum infection factors and NT-proBNP in lung cancer patients during perioperative period

作　　者：吕定量[1] 万海军[1] 邱水玮 于进江 邱燕军[1] LYU Ding-liang;WAN Hai-jun;QIU Shui-wei;YU Jin-jiang;QIU Yan-jun(Quzhou People's Hospital,Quzhou,Zhejiang 324000,China)

机构地区：[1]衢州市人民医院心胸外科

出　　处：《中华医院感染学杂志》2019年第1期78-80,共3页Chinese Journal of Nosocomiology

基　　金：衢州市科技局科研基金资助项目(2015103002)

摘　　要：目的探索肺癌患者围手术期血清炎症因子与N末端脑钠肽(NT-proBNP)的变化情况及其对并发症的影响。方法选取2015年6月-2017年5月在医院接受治疗的63例肺癌患者为研究对象,比较患者手术前后降钙素原(PCT)、C-反应蛋白(CRP)、白细胞介素6(IL-6)等血清炎症因子和NT-proBNP指标水平,统计患者手术后并发症发生情况。采集感染患者临床标本进行病原菌培养及鉴定。结果肺癌患者手术后PCT为(16.59±3.57)ng/ml,IL-6为(124.07±30.44)pg/ml,CRP为(467.13±43.66)mg/L,NT-proBNP为(265.38±26.13)pg/ml,均高于手术前PCT(1.32±0.08)ng/ml,IL-6(16.89±4.11)pg/ml,CRP(10.27±1.39)mg/L,NT-proBNP(67.18±12.47)pg/ml,比较差异有统计学意义(P<0.05)。15例肺癌患者术后出现并发症,发生率为23.81%;其中11例肺部感染占73.33%。术后感染患者共检测出16株病原菌,革兰阳性菌7株,革兰阴性菌9株。结论肺癌患者手术后血清感染因子和NT-proBNP指标水平显著高于手术前各项指标水平,且肺癌患者手术后感染并发症及心脏并发症发生率均较高,血清感染因子和NT-proBNP可以为术前预测肺癌患者并发症提供有效依据。OBJECTIVE To explore the changes of serum inflammatory factors and N-terminal brain natriuretic peptide(NT-proBNP)in the lung cancer patients during perioperative period and observe the influence on complications.METHODS A total of 63 lung cancer patients who were treated in the hospital from Jun 2015 to May 2017 were recruited as the study objects,the levels of serum inflammatory factors such as procalcitonin(PCT),C-reactive protein(CRP)and interleukin-6(IL-6)as well as NT-proBNP of the patients were observed and compared before and after the surgery,the incidence rates of postoperative complications were statistically analyzed,the clinical specimens were collected from the patients with infection and cultured for pathogens,and the isolated pathogens were identified.RESULTS The levels of PCT,IL-6,CRP and NT-proBNP of the lung cancer patients were respectively(16.59±3.57)ng/ml,(124.07±30.44)pg/ml,(467.13±43.66)mg/L and(265.38±26.13)pg/ml after the surgery,significantly higher than(1.32±0.08)ng/ml,(16.89±4.11)pg/ml,(10.27±1.39)mg/L and(67.18±12.47)pg/ml before the surgery(P<0.05).Totally 15 lung cancer patients had postoperative complications,with the incidence rate 23.81%,11(73.33%)of whom had pulmonary infection.A total of 16 strains of pathogens were isolated from the patients with postoperative infection,7 of which were gram-positive bacteria,and 9 were gram-negative bacteria.CONCLUSIONThe levels of serum inflammatory factors and NT-proBNP of the lung cancer patients are remarkably higher after the surgery than before the surgery,and the incidence rates of infectious complications and cardiac complications are higher after the surgery than before the surgery.The serum inflammatory factors and NT-proBNP may provide effective evidence for the prediction of complications in the lung cancer patients.

关 键 词：肺癌 血清感染因子 N末端脑钠肽 围手术期 改变 

分 类 号：R734.1[医药卫生—肿瘤]