肝炎病毒载量与恶性肿瘤特异性生长因子相关性分析  

Relationship between hepatitis virus load and TSGF

作　　者：齐发梅[1] 魏莲花[1] 周爱花[1] 尹会媛 张宇钧[1] 石福娜 QI Fa-mei;WEI Lian-hua;ZHOU Ai-hua;YIN Hui-yuan;ZHANG Yu-jun;SHI Fu-na(Clinical Laboratory,Gansu Provincial Hospital,Lanzhou,Gansu 730000,China)

机构地区：[1]甘肃省人民医院,甘肃兰州730000

出　　处：《中国卫生检验杂志》2019年第4期430-431,437,共3页Chinese Journal of Health Laboratory Technology

基　　金：国家高技术研究发展计划(863计划)子课题(2014AA-022304)

摘　　要：目的分析恶性肿瘤特异性生长因子(TSGF)在乙型肝炎、丙型肝炎、肝硬化及肝癌患者中的表达水平,旨在探讨TSGF在肝病进展过程中的临床意义。方法选择甘肃省人民医院住院的已确诊的乙型肝炎患者173例,丙型肝炎患者54例,用MX-3000P荧光定量PCR扩增仪,检测HBV-DNA、HCV-RNA。通过B超、CT、病理等确诊的肝硬化及肝癌患者49例为疾病组;健康体检人群115例作为对照组。采用Olympus 5400全自动生化分析仪检测TSGF;数据采用SPSS 22.0统计软件进行分析。结果乙型肝炎、丙型肝炎TSGF水平2组之间及正常对照组之间差异均无统计学意义(P>0.05);与肝硬化及肝癌组比较,差异有统计学意义(P<0.05)。乙型肝炎组病毒复制与不复制组之间TSGF水平差异无统计学意义(P>0.05)。丙型肝炎组病毒复制与不复制组之间TSGF水平差异无统计学意义(P>0.05)。结论 TSGF水平随着肝脏疾病发展,具有增高趋势,在肝硬化及肝癌患者中有高表达,可以作为肝炎、肝硬化或肝癌鉴别诊断的辅助指标。Objective To analyze the expression of tumor specific growth factor(TSGF) in patients with hepatitis B, hepatitis C, liver cirrhosis and liver cancer, and to explore the clinical significance of TSGF in the progression of liver disease. Methods Totally 73 patients with confirmed hepatitis B and 54 patients with hepatitis C were admitted to the People′s Hospital of Gansu Province. HBV-DNA and HCV-RNA were detected by US MX-3000 P fluorescent quantitative PCR instrument. Forty-eight patients with liver cirrhosis and liver cancer diagnosed by B-ultrasound, CT and pathology were included as case group;115 healthy people were selected as control group. TSGF was detected by Olympus 5400 automatic biochemical analyzer;and data was analyzed by SPSS 22.0 statistical software. Results There was no statistical significance on the difference of TSGF level between hepatitis B group, hepatitis C group and control group(P>0.05). There was statistical significance on the differences in TSGF levels compared with cirrhosis group and liver cancer group(P<0.05). There was no statistical significance on the difference in TSGF levels between virus replication group and non-replication group in the hepatitis B group(P>0.05). There was no statistical significance on the difference in TSGF levels between the virus replication group and non-replication group in the hepatitis C group(P>0.05). Conclusion TSGF level has an increasing trend with the development of liver disease, and it is highly expressed in patients with cirrhosis and liver cancer. It can be used as an auxiliary indicator for the differential diagnosis of hepatitis, liver cirrhosis or liver cancer.

关 键 词：恶性肿瘤特异性生长因子 肝炎 病毒载量 

分 类 号：R735.7[医药卫生—肿瘤]