One-pot photoreduction to prepare NIR-absorbing plasmonic gold nanoparticles tethered by amphiphilic polypeptide copolymer for synergistic photothermal-chemotherapy  

作　　者：Siqi Yang Linzhu Zhou Yue Su Rong Zhang Chang-Ming Dong 

机构地区：[1]School of Chemistry and Chemical Engineering, Shanghai Key Laboratory of Electrical Insulation and Thermal Aging, Shanghai Jiao Tong University [2]Joint Research Center for Precision Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital South Campus, Shanghai Fengxian Central Hospital

出　　处：《Chinese Chemical Letters》2019年第1期187-191,共5页中国化学快报（英文版）

基　　金：The National Natural Science Foundation of China (No. 21474061);The Innovation Fund (No. IFPM2016B004) of Shanghai Jiao Tong University & Affiliated Sixth People's Hospital South Campus are appreciated

摘　　要：We developed one-pot photoreduction strategy to prepare near infrared light(NIR)-absorbing plasmonic gold nanoparticles(Au NPs) tethered by amphiphilic polypeptide copolymer poly(L-cysteine)-b-poly(ethylene oxide)(PLC-b-PEO). The PLC-b-PEO@Au NPs possessed strong NIR absorption at 700–1100 nm and ultrahigh photothermal conversion efficiency of 62.1%. Upon the NIR irradiation(808nm,2 W/cm^2,5 min), the PLC-b-PEO@Au NPs(1mg/mL) sharply attained an elevation of 30.8℃ and the hyperthermia effect could efficiently kill cancer cells in vitro. As for the PT-CT treatment, the doxorubicin(DOX)-loaded nanoparticles of DOX-PLC-b-PEO@Au NPs gave a combination index of 0.9 compared to single chemotherapy(CT) or photothermal therapy(PT), demonstrating a synergistic effect.We developed one-pot photoreduction strategy to prepare near infrared light(NIR)-absorbing plasmonic gold nanoparticles(Au NPs) tethered by amphiphilic polypeptide copolymer poly(L-cysteine)-b-poly(ethylene oxide)(PLC-b-PEO). The PLC-b-PEO@Au NPs possessed strong NIR absorption at 700–1100 nm and ultrahigh photothermal conversion efficiency of 62.1%. Upon the NIR irradiation(808nm,2 W/cm^2,5 min), the PLC-b-PEO@Au NPs(1mg/mL) sharply attained an elevation of 30.8℃ and the hyperthermia effect could efficiently kill cancer cells in vitro. As for the PT-CT treatment, the doxorubicin(DOX)-loaded nanoparticles of DOX-PLC-b-PEO@Au NPs gave a combination index of 0.9 compared to single chemotherapy(CT) or photothermal therapy(PT), demonstrating a synergistic effect.

关 键 词：Near infrared PLASMONIC gold nanoparticles POLYPEPTIDE PHOTOTHERMAL THERAPY Combination THERAPY 

分 类 号：O6[理学—化学]