前列腺癌耐药机制的研究进展  

Research advances in the mechanisms of drug resistance in prostate cancer

作　　者：王嘉兴 林平 陈正坤 林锋 Wang Jiaxing;Lin Ping;Chen Zhengkun;Lin Feng(Department of Organic Chemistry,College of Pharmacy,Harbin Medical University,Harbin 150081,China;Department of Biochemistry and Molecular Biology,College of Basic Medical Science,Harbin Medical University,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学药学院有机化学教研室,150081 [2]哈尔滨医科大学基础医学院生物化学与分子生物学教研室,150081

出　　处：《国际免疫学杂志》2019年第1期52-57,共6页International Journal of Immunology

基　　金：国家自然科学基金(81502199);2017年黑龙江省级大学生创新创业训练计划项目(201710226032).

摘　　要：前列腺癌是男性常见恶性肿瘤,内分泌药物治疗是前列腺癌有效的治疗手段,然而患者易产生耐药性,对前列腺癌治疗产生极大影响。雄激素受体、肿瘤微环境、炎性细胞因子、肿瘤干细胞及上皮间质转化与前列腺癌进程及耐药性的产生密切相关。现结合以往的研究报道,对前列腺癌耐药机制展开综述,以期待为前列腺癌治疗提供新思路和新靶标。Prostate cancer is one of the common malignancies.Drug treatment is one of the effective treatments for prostate cancer,while the emergence of drug resistance has a great impact on the cancer treatment.Androgen receptor,tumor microenvironment,inflammatory cytokine,cancer stem cells and epithelial-mesenchymal transition are closely related to prostate cancer progression and drug resistance.Here the mechanism of drug resistance in prostate cancer is reviewed,hoping to provide some new ideas and new targets for prostate cancer treatment.

关 键 词：前列腺癌 耐药 雄激素受体 肿瘤微环境 炎性细胞因子 肿瘤干细胞 上皮间质转化 

分 类 号：R737.25[医药卫生—肿瘤]