未服药精神分裂症患者血清IL-2、IL-4、IL-6、IL-10和IL-17A的水平  

The levels of IL-2,IL-4,IL-6,IL-10 and IL-17A in serum of medication naive patients with schizophrenia

作　　者：孙志刚[1] 李素水[1] 范彦蓉[1] 薛曼[1] 王斌[1] 郭年春[1] SUN Zhigang;LI Sushui;FAN Yanrong(The Eighth Hospital of Shijiazhuang City ,Shijiazhuang 050081,China)

机构地区：[1]河北省石家庄市第八医院

出　　处：《中国健康心理学杂志》2019年第1期1-3,共3页China Journal of Health Psychology

基　　金：河北省高层次人才资助项目(编号:A2016002087);河北省科技计划项目(编号:152777223)

摘　　要：目的:探讨未服药的精神分裂症患者血清白细胞介素2(interleukin 2,IL-2)、IL-4、IL-6、IL-10和IL-17A水平以及和症状之间的相关性。方法:选取2015年3月-2017年3月在我院精神科住院的精神分裂症患者38例为研究对象,以我院的健康医护人员30例作为对照组。采用酶联免疫吸附试验检测血清各IL浓度,应用阳性和阴性症状量表(PANSS)评定症状的严重性。结果:研究组的血清IL-6水平为(25.03±11.23)pg/ml显著高于对照组的(19.02±9.49)pg/ml,差异有统计学意义(t=2.343,P<0.05);其余各血清IL水平两组差异无统计学意义。血清IL-6水平与PANSS总分呈正相关,主要与阴性症状和一般病理学症状有关(r=0.470,0.343,0.335;P<0.05)。结论:精神分裂症起病的早期阶段机体存在炎性反应活化状态,血清IL-6水平有望成为早期诊断精神分裂症的外周免疫标记物。Objective:To investigate the levels interleukin 2(IL-2),IL-4,IL-6,IL-10 and IL-17 Alevels in serum of medication naive patients with schizophrenia and the correlation between serum interleukin levels and symptoms.Methods:A total of 38 cases of schizophrenia patients admitted to psychiatric department of our hospital were selected as study object from March 2015 to March 2017.Meanwhile,30 apparently our hospital health care workers were selected as a control group.Serum concentrations of IL were detected by enzyme-linked immunosorbent assay,and the severity of symptoms was assessed using the positive and negative symptom scales.Results:The level of serum IL-6 in the study group was significantly higher than that of the control group(t=2.343,P<0.05).The remaining serum IL levels were not significant different between the two groups.The serum IL-6 level was positively correlated with the total score of PANSS,that mainly related to negative symptoms and general pathological symptoms(r=0.470,0.343,0.335;P<0.05).Conclusion:In the early stages of the onset of schizophrenia,the body has inflammatory reaction activated state.Serum IL-6 levels are expected to be peripheral immune markers for early diagnosis of schizophrenia.

关 键 词：精神分裂症 白细胞介素 阳性症状 阴性症状 

分 类 号：R749.3[医药卫生—神经病学与精神病学]