肠黏液层构成及其与相关疾病关系  

The composition of intestinal mucous layer and its relationship with associated diseases

作　　者：王华伟 赵浩天[2] 蒋小芝 赵鹤龄[1,2] WANG Hua-wei;ZHAO Hao-tian;JIANG Xiao-zhi;ZHAO He-ling(Graduate College of Hebei Medical University,Shijiazhuang 050057,Hebei,China;Hebei People's Hospital ICU,Shijiazhuang 050051,Hebei,China;Graduate College of Heibei North University,Zhangjiakou 075000,Hebei,China)

机构地区：[1]河北医科大学研究生学院,河北石家庄050057 [2]河北省人民医院ICU,河北石家庄050051 [3]北方学院研究生学院,河北张家口075000

出　　处：《肠外与肠内营养》2019年第1期61-64,共4页Parenteral & Enteral Nutrition

基　　金：2015年度河北省医学科学研究重点课题(20150119)

摘　　要：肠黏液层是哺乳动物肠道上皮细胞上面附着的一层保护性凝胶型液体,它是宿主与肠道内环境接触的第一道屏障。肠黏液层作为肠腔内容物与肠道上皮细胞之间的润滑液和物理屏障,与肠道的机械屏障、免疫屏障及生物屏障均关系密切。尤其是在危重症病人疾病的发展过程中,黏液层、肠腔内消化酶和系统缺血再灌注损伤是一个复杂的过程,肠壁缺血再灌注损伤是引起黏液层结构和功能完整性受损的始发因素,此损伤启动后使得消化酶进入肠腔,然后启动自身消化反应,从而导致肠源性的脓毒症、急性肺损伤和多脏器衰竭。近几十年来对其研究较少,本文将从肠道黏液层构造及与疾病的关系做一综述。The intestinal mucosa is a protective gel-liquid layer attached to epithelial cells of mammals. It is the first barrier for the host to intestinal environment. As a lubricant and physical barrier between intestinal cavity contents and intestinal epithelial cells, intestinal mucus is closely related to intestinal mechanical barrier, immune barrier and biological barrier. The disease development in critically ill patients is complex in mucous layer, intestinal digestive enzyme system and ischemia reperfusion injury. Intestinal ischemia reperfusion injury causes impaired structural and functional integrity, which enables the infiltration of digestive enzymes into intestinal lumen. Subsequently autodigestion results in gut-derived sepsis, acute lung injury and multiple organ failure. The above topic is less studied in recent decades. This paper will review the relationship between the structure of intestinal mucous layer and the associated diseases.

关 键 词：肠黏膜屏障 化学屏障 黏液层 肠道菌群 

分 类 号：R574[医药卫生—消化系统]