临床应用含磷药物结构特点的综述  

Review on the Structures of Phosphorus-containing Drugs Used in Clinical Practice

作　　者：姚秋丽 任林静 冉茂刚 何佳芯 向丹 YAO Qiu-li;REN Lin-jing;RAN Mao-gang;HE Jia-xin;XIANG Dan(School of Pharmacy,Zunyi Medical University,Zunyi 563000,China)

机构地区：[1]遵义医科大学药学院,贵州遵义563000

出　　处：《化学试剂》2019年第2期139-146,共8页Chemical Reagents

基　　金：国家自然科学基金资助项目(21462056;21801261);贵州省联合基金资助项目([2014]7542);遵义医学院项目(201710661019;F-627)

摘　　要：临床上使用的含磷药物结构丰富、活性各异,但目前极少有文献针对含磷药物的结构特征和由于含磷基团的引入而对临床应用特点产生影响进行综述的,这无疑给进一步探索具有潜在生物活性的含磷化合物的设计和合成带来诸多不便。针对该情况,将临床中使用的含磷药物按照其结构特点进行分类,阐述含磷基团的引入对药物活性的影响,为含磷新药物的研发提供思路。Phosphorus-containing drugs have various structures and show diverse clinical activities. Only few literatures had ever reviewed the structural features and the corresponding characteristics of clinical activities.This undoubtely makes inconvenience in the design and synthesis of phosphorus-containing compounds with potential biological acitivities.Phosphorus-containing drugs according to their characteristics of structures were categorized.The effect of the introduction of phosphorus-containing groups on the drug activity was discussed,hoping to provide solutions for the design of new phosphorus-containing drugs.

关 键 词：含磷药物 前药 磷酸盐 膦酸盐 

分 类 号：R914.4[医药卫生—药物化学]