八珍颗粒辅助化疗对晚期胃癌细胞免疫指标和P53蛋白、IL-6表达的影响  

Effects of Bazhen Granule adjuvant chemotherapy on cellular immunity indexes and expression of P53 protein and IL-6 in advanced gastric cancer

作　　者：钱晓兰[1] 左云[1] QIAN Xiaolan;ZUO Yun(Department of Oncology ,the First People's Hospital of Zhangjiagang,Zhangjiagang 215600,China)

机构地区：[1]张家港市第一人民医院肿瘤科,江苏张家港215600

出　　处：《现代医学》2018年第12期1339-1344,共6页Modern Medical Journal

基　　金：2016年江苏省青年医学重点人才培养项目(QNRC2016264)

摘　　要：目的:观察八珍颗粒辅助氟尿嘧啶+吡柔比星+奥沙利铂治疗晚期胃癌临床疗效及对细胞免疫指标和P53蛋白、白细胞介素-6(IL-6)表达的影响。方法:将80例晚期胃癌患者随机分为2组,对照组40例给予氟尿嘧啶+吡柔比星+奥沙利铂治疗,研究组40例在对照组基础上给予八珍颗粒辅助治疗,两组均以3周为1个疗程,持续治疗2个疗程。对比两组临床疗效,检测治疗前后细胞免疫指标和血清P53蛋白、IL-6表达水平,统计治疗期间不良反应发生情况。结果:研究组临床治疗总有效率为67. 50%,显著高于对照组的40. 00%(P <0. 05);两组治疗后CD3+、CD4+、CD4+/CD8+和NK细胞水平均较治疗前显著升高(P <0. 05),CD8+水平均较治疗前显著降低(P <0. 05),且研究组CD3+、CD4+、CD8+、CD4+/CD8+和NK细胞水平均高于对照组(P <0. 05);两组治疗后血清P53蛋白、IL-6表达水平均较治疗前显著降低(P <0. 05),且研究组血清P53蛋白、IL-6表达水平均显著低于对照组(P <0. 05)。研究组治疗期间不良反应发生率显著低于对照组(P <0. 05)。结论:八珍颗粒辅助氟尿嘧啶+吡柔比星+奥沙利铂治疗晚期胃癌临床疗效显著,能明显改善细胞免疫指标,降低血清P53蛋白、IL-6表达水平。Objective: To observe the clinical curative effect of Bazhen Granule assisted with Fluorouracil +Pirarubicin + Oxaliplatin in treatment of advanced gastric cancer and its influences on cellular immunity index and the expressions of P53 protein and interleukin-6( IL-6). Methods: 80 patients with advanced gastric cancer were randomly divided into two groups,40 cases in control group were given Fluorouracil + Pirarubicin + Oxaliplatin treatment,40 cases in study group were given Bazhen Granule on the basis of the control group,the two groups were treated for 2 courses continuously,each course was 3 weeks. The clinical efficacy of the two groups after treatment was compared,the cellular immunity index and the expressions of P53 protein and interleukin-6 were detected in two groups before and after treatment,the incidence of adverse reactions during the treatment of the two groups was statistically analyzed. Results: The total effective rate of clinical treatment in the study group was67. 50%,which was significantly higher than 40. 00% in the control group( P < 0. 05);after treatment,the levels of CD3^+,CD4^+,CD4^+/CD8^+ and NK cell in the two groups were significantly higher than those before treatment( P < 0. 05),and CD8^+ levels were significantly lower than those before treatment( P < 0. 05),the levels of CD3^+,CD4^+,CD8^+,CD4^+/CD8^+ and NK cell in the study group were better than those in the control group( P <0. 05);after treatment,the levels of P53 protein and IL-6 in the two groups were significantly lower than those before treatment( P < 0. 05),the levels of serum P53 protein and IL-6 in the study group were significantly lower than those in the control group( P < 0. 05). The incidence rate of adverse reactions in the study group during the treatment was significantly lower than that in the control group( P < 0. 05). Conclusion: The clinical curative effect of Bazhen Granule assisted with Fluorouracil + Pirarubicin + Oxaliplatin in treatment of advanced gastric cancer is significant,it can significantly impr

关 键 词：八珍颗粒 胃癌 细胞免疫 P53蛋白 白细胞介素-6 

分 类 号：R735.2[医药卫生—肿瘤]