慢加急性肝功能衰竭伴肾功能不全选择肝移植或肝肾联合移植治疗效果分析  

Effect analysis of liver transplantation or combined liver and kidney transplantation for chronic and acute liver failure with renal insufficiency

作　　者：赵云峰 曲青山[1] 苗书斋[1] Zhao Yunfeng;Qu Qingshan;Miao Shuzhai(Department of Organ Transplantation,Zhengzhou People's Hospital,Zhengzhou 450003,China)

机构地区：[1]郑州人民医院器官移植科,450003

出　　处：《国际移植与血液净化杂志》2018年第6期23-25,共3页International Journal of Transplantation and Hemopurification

摘　　要：目的探讨慢加急性肝功能衰竭伴肾功能不全选择肝移植或肝肾联合移植治疗的效果。方法选取我院2012年4月至2018年4月收治的慢加急性肝功能衰竭伴肾功能不全患者90例,随机分为对照组和观察组。对照组予以肝移植治疗,观察组则予以肝移植联合肾移植治疗。比较两组患者1年存活率、住院时间、监护室治疗时间、呼吸机支持时间、治疗前后患者生存质量、院内死亡率。结果观察组1年存活率高于对照组(P<0.05),住院时间、监护室治疗时间、呼吸机支持时间长于对照组(P<0.05)。治疗前两组生存质量并无明显差异(P>0.05),治疗后观察组生存质量优于对照组(P<0.05)。观察组院内死亡率低于对照组(P<0.05)。结论肝移植联合肾移植治疗慢加急性肝功能衰竭伴肾功能不全的治疗效果确切,可有效提高1年存活率,降低院内死亡率,改善生存质量,值得推广应用。Objective to explore the therapeutic effect of liver transplantation or combined liver and kidney transplantation for chronic and acute liver failure with renal insufficiency. Methods From April 2012 to April 2018, 90 cases of patients with chronic and acute liver failure with renal insufficiency were randomly divided into control group and observation group. The control group received liver transplantation and the observation group received liver transplantation combined with kidney transplantation. One year survival rate, hospitalization time, custody time, ventilator support time, quality of life before and after treatment, hospital mortality was compared between the two groups. Results the 1-year survival rate of the observation group was higher than that of the control group(P<0.05). The duration of hospitalization, custody and ventilator support in the observation group was longer than that in the control group(P<0.05). There was no significant difference in the quality of life between the two groups before treatment(P>0.05). The quality of life of the observation group was better than that of the control group after treatment(P<0.05). The hospital mortality rate of the observation group was lower than that of the control group(P<0.05). Conclusion Liver transplantation combined with kidney transplantation for the treatment of chronic and acute liver failure with renal insufficiency is effective in improving survival rate, mortality and quality of life.

关 键 词：慢加急性肝功能衰竭伴肾功能不全 肝移植 肝肾联合移植 治疗效果 

分 类 号：R575.3[医药卫生—消化系统]