胰腺导管腺癌细胞基质研究  

Study on cell matrix of pancreatic duct adenocarcinoma

作　　者：邢荣春[1] 秦周萍 Xing Rongchun;Qin Zhouping(Department of Emergency and Trauma Surgery,First College of Clinical Medical Sciences,China Three Gorges University, Yichang 443003,China)

机构地区：[1]三峡大学第一临床医学院急诊与创伤外科,宜昌443003 [2]三峡大学人民医院胸心外科

出　　处：《国际肿瘤学杂志》2018年第11期696-698,共3页Journal of International Oncology

摘　　要：胰腺导管腺癌(PDAC)的发生与其癌细胞造血基质生物免疫学特征密切相关,癌细胞基质的恶性特征在肿瘤恶性起源、逃避免疫监视、促进肿瘤进展和生长以及增加耐药性和转移方面发挥着重要作用。了解PDAC细胞造血基质中透明质酸、Sonic Hedgehog信号通路、转化生长因子-β、CD40、Kras通路以及微小RNA等在PDAC发生发展中的重要作用,可为临床治疗PDAC提供新的策略。The occurrence of pancreatic duct adenocarcinoma (PDAC) is closely related to the biological immunological characteristics of the hematopoietic matrix of its cancer cells. The malignant characteristics of the cancer matrix play important roles in the malignant origin of tumors, avoiding immune surveillance, promoting tumor progression and growth, and increasing drug resistance and metastasis. Understanding the important roles of hyaluronic acid, Sonic Hedgehog signaling pathway, transforming growth factor-beta, CD40, Kras pathway and microRNA in the pathogenesis and development of PDAC, can provide new strategies for clinical treatment of PDAC.

关 键 词：癌 胰腺管 信号传导 细胞外基质 肿瘤微环境 

分 类 号：R735.9[医药卫生—肿瘤]