紫杉醇联合奥沙利铂及氟尿嘧啶与奥沙利铂联合氟尿嘧啶辅助化疗Ⅲ期胃癌D2根治术的疗效比较  

Comparison of the efficacy of paclitaxel combined with oxaliplatin and fluorouracil and oxaliplatin combined with fluorouracil as adjuvant chemotherapy in the treatment of stage Ⅲ gastric cancer after D2 gastrectomy

作　　者：陈丽珠[1] 陈誉[1] 林晶[1] 郑静娴[1] 陈玲[1] 郭增清[1] CHEN Lizhu;CHEN Yu;LIN Jing;ZHENG Jingxian;CHEN Ling;GUO Zengqing(Department of Oncology,Fujian Provincial Cancer Hospital,Fujian Provincial Key Laboratory of Tumor Biotherapy,Fujian Key Laboratory of Translational Cancer Medicine,Fuzhou,Fujian 350014,China)

机构地区：[1]福建省肿瘤医院肿瘤内科福建省肿瘤生物治疗重点实验室福建省肿瘤转化医学重点实验室

出　　处：《徐州医科大学学报》2019年第1期1-5,共5页Journal of Xuzhou Medical University

基　　金：国家自然科学基金(U1705282);福建省自然科学基金(2017J01259,2018J01267);福建省卫生计生委课题基金(2015-CX-7,2018-ZQN-13,2016-1-11,2018-1-13);福建省科技创新联合资金项目(2017Y9077);国家临床重点专科建设项目

摘　　要：目的比较紫杉醇联合奥沙利铂及氟尿嘧啶(POF)和奥沙利铂联合氟尿嘧啶(FOLFOX)作为Ⅲ期胃癌D2根治术后辅助化疗方案的疗效及安全性。方法回顾性分析2011年1月至2014年12月于我院肿瘤内科就诊的Ⅲ期胃癌D2根治术后的患者的临床资料,共66例。其中接受POF方案辅助化疗24例,接受FOLFOX方案化疗42例。比较这些患者无疾病生存期(DFS)以及相关不良反应。结果POF组和FOLFOX组患者中位DFS分别为16个月和11个月(HR:0.558;95%CI:0.314~0.990,P=0.046),差异有统计学意义(P<0.05)。两组的不良反应均主要为消化道反应、外周神经毒性及骨髓抑制,差异元统计学意义(P>0.05),且两组患者均能够能耐受。结论POF方案对Ⅲ期胃癌D2根治术后患者的辅助化疗优于FOLFOX方案,且不良反应多能耐受。Objective To compare the efficacy and safety of paclitaxel combined with oxaliplatin and fluorouracil (POF)and oxaliplatin and fluorouraeil (FOLFOX)as adjuvant chemotherapy in the treatment of stage Ⅲ gastric cancer after D2 gastrectomy.Methods Retrospective analysis was performed using clinical data from 66 patients with stage Ⅲ gastric cancer after D2 gastreetomy in our hospital from January 2011 to December 2014.The patients were divided into two groups according to their treatment regimens :a POF group (n =24)and an FOLFOX group (n =42).Then,the two groups were compared for disease free survival (DFS)and adverse reactions.Results The DFS was 16 months for the POF group and Ⅲ months for the FOLFOX group (HR:0.558;95%.CI:0.314-0.990;P =0.046).The main adverse reactions of the two groups were gastrointestinal reaction,peripheral neurotoxicity and myelosuppression,without statistical difference (P >0.05),and both groups were able to tolerate.Conclusions POF regimen is superior to FOLFOX as adjuvant chemotherapy for patients with stage Ⅲ gastric cancer after D2 radical resection,with tolerable adverse reactions.

关 键 词：紫杉醇 奥沙利铂 氟尿嘧啶 Ⅲ期胃癌D2根治术 辅助化疗 

分 类 号：R735.2[医药卫生—肿瘤]