创伤后应激障碍脑结构变化的磁共振研究进展  

Progress in magnetic resonance imaging of brain structural changes in post-traumatic stress disorder

作　　者：马庆鑫[1] 蒋丽莎[2] 朱鸿儒[1] 张伟[1] MA Qingxin;JIANG Lisha;ZHU Hongru ;ZHANG Wei(Mental Health Center,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,P.R.China;Day Surgery Center,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,P.11.China)

机构地区：[1]四川大学华西医院心理卫生中心,成都610041 [2]四川大学华西医院日间服务中心,成都610041

出　　处：《华西医学》2019年第2期213-217,共5页West China Medical Journal

基　　金：国家自然科学基金(81371484)

摘　　要：创伤后应激障碍(post-traumatic stress disorder,PTSD)是精神科常见的慢性疾病之一,其病程较长,严重影响患者的生活和工作,对社会功能有严重影响。目前对于PTSD的诊断局限于临床症状表现以及医师经验判断,并未发现确切的病变物质基础,而病变物质基础对于准确的诊断、有效治疗方法的选择、治疗结果的评估和残疾评估是至关重要的。头部MRI目前是解决这一问题最有前景的技术之一。该文综述了PTSD患者脑结构变化MRI的研究现状,旨在探讨今后可能的发展方向。Post-traumatic stress disorder(PTSD) is one of the common chronic diseases in psychiatry. It has a long course of disease which seriously affects patient’s life and work, and has a serious impact on social function. So far, the diagnosis of PTSD is limited to clinical symptom manifestations and physician experience, and no exact pathological substance basis is found, while the pathological substance basis is crucial for accurate diagnosis, selection of effective treatment methods, evaluation of treatment results, and assessment of disability. Head MRI is currently one of the most promising techniques to solve this problem. This paper reviews the progress in MRI research on brain structure changes in PTSD patients, in order to explore the possible future development directions.

关 键 词：创伤后应激障碍 磁共振成像 前扣带皮质 海马 胼胝体 

分 类 号：R749.5[医药卫生—神经病学与精神病学]