Application of Enzymatic Promiscuity in Pharmaceutical Synthesis:Papain-catalyzed One-pot Synthesis of 1,4-Dihydropyridine Calcium Channel Antagonists and Derivatives  

作　　者：JIANG Ling YE Wenting SU Weike YU Chuanming 

机构地区：[1]Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology,Hangzhou 310014,P.R.China [2]Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education College of Pharmaceutical Sciences,Zhejiang University of Technology Hangzhou 310014,P.R.China

出　　处：《Chemical Research in Chinese Universities》2019年第1期21-25,共5页高等学校化学研究（英文版）

基　　金：the National Natural Science Foundation of China(No.21706236);the China Postdoctoral Science Foundation (No.2016M592012);the Foundation for Selected Postdoctoral Project of Zhejiang Province,China(No.BSH1502150).

摘　　要：A new method for the synthesis of 1,4-dihydropyridine(1,4-DHP)calcium channel antagonists felodipme, nitrendipine and their derivatives via papain-catalyzed three-component reactions of aldehyde,methyl acetoacetate and ethyl 3-aminocrotonate was developed.Operational simplicity,mild reaction conditions and eco-friendliness are the key features of this protocol.

关 键 词：PAPAIN Catalytic PROMISCUITY Multicomponent reaction 1 4-DIHYDROPYRIDINE calcium channel ANTAGONIST 

分 类 号：O6[理学—化学]